Toxic chemicals used in product design and manufacturing are grave concerns due to their significant impact on human health. Sustainable material selections are needed by industry to reduce the overall impact of toxic chemicals in both design and manufacturing. In this paper, we integrate the human health impact assessment into standard material selection process for developing a sustainable material selection metric for decision support in design and manufacturing. A schematic method is presented for characterizing and benchmarking the human health impact of toxic chemicals. A case study is performed on six toxic chemicals used as solvents in semiconductor manufacturing. Reliability of the schematic benchmarking results is checked and validated by comparing the results with that of conventional Human Toxicity Potential (HTP) method.

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