The human cerebral cortex undergoes folding from the 5th fetal month into the first post-natal year. Disturbances of folding have serious and lasting consequences, but the mechanism is not well understood. Van Essen  has hypothesized that axonal tension between strongly interconnected regions draws them together and induces outward folds. However, no direct measurements have confirmed this theory. Experimental data are needed, beginning with a quantitative description of the kinematics of cortical growth during folding.
MRI Measurement of Surface Strain Due to Growth in the Developing Ferret Brain
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Knutsen, AK, Kroenke, CD, Taber, LA, Neil, JJ, & Bayly, PV. "MRI Measurement of Surface Strain Due to Growth in the Developing Ferret Brain." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 551-552. ASME. https://doi.org/10.1115/SBC2007-176010
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