The airway closure due to capillary instability [1] occurs in lung diseases such as asthma, cystic fibrosis, or emphysema. The reopening process involves displacement of plugs constituted from mucus, a non-Newtonian fluid with a yield stress, in the airways. In this work the transient propagation of mucus plugs in a 2D channel is studied numerically, assuming that the mucus is a Bingham fluid. The governing equations are discretized by a spectral element formulation and the free surface is resolved with an Arbitrary Lagrangian Eulerian (ALE) approach [2]. The constitutive equation for a Bingham fluid is implemented through a regularized constitutive equation. According to the numerical results, the yield stress behavior of the plug modifies the plug shape, the pattern of the streamlines and the distribution of stresses in the plug domain and along the walls in a significant way. The distribution along the walls is a major factor in studying cell injuries.
Skip Nav Destination
ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Transient Motion of Liquid Plugs With Yield Stress in Human Airways
Parsa Zamankhan,
Parsa Zamankhan
University of Michigan, Ann Arbor, MI
Search for other works by this author on:
Brian Helenbrook,
Brian Helenbrook
Clarkson University, Potsdam, NY
Search for other works by this author on:
Shuichi Takayama,
Shuichi Takayama
University of Michigan, Ann Arbor, MI
Search for other works by this author on:
James B. Grotberg
James B. Grotberg
University of Michigan, Ann Arbor, MI
Search for other works by this author on:
Parsa Zamankhan
University of Michigan, Ann Arbor, MI
Brian Helenbrook
Clarkson University, Potsdam, NY
Shuichi Takayama
University of Michigan, Ann Arbor, MI
James B. Grotberg
University of Michigan, Ann Arbor, MI
Paper No:
SBC2011-53609, pp. 1331-1332; 2 pages
Published Online:
July 17, 2013
Citation
Zamankhan, P, Helenbrook, B, Takayama, S, & Grotberg, JB. "Transient Motion of Liquid Plugs With Yield Stress in Human Airways." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 1331-1332. ASME. https://doi.org/10.1115/SBC2011-53609
Download citation file:
13
Views
Related Articles
Mass Transfer From a Rotating Disk to a Bingham Fluid
J. Appl. Mech (January,2006)
Modeling Flow of a Biviscous Fluid From Borehole Into Rock Fracture
J. Appl. Mech (January,2006)
Design of Pressurized Metered Dose Inhalers Modeling of Internal Flow and Atomization
J. Med. Devices (June,2010)
Related Chapters
Experimental Studies
Nanoparticles and Brain Tumor Treatment
Flexibility Analysis
Process Piping: The Complete Guide to ASME B31.3, Third Edition
The Effect of Anterior Cruciate Ligament Injury on Tibiofemoral Joint Biomechanics: Under Draw Load
International Conference on Mechanical Engineering and Technology (ICMET-London 2011)