Left ventricular assist device (LVAD) therapy has become an established treatment for patients with end-stage heart failure as either a bridge to transplant (BTT) or as permanent support (destination therapy: DT) . For a small portion of patients, LVAD could be used as a bridge to cardiac recovery (BTR). Recent clinical studies have demonstrated the advantages of continuous-flow LVADs over pulsatile-flow counterparts with respect to higher survival rates and lower incidence of major adverse events . However, the control challenge of continuous-flow LVADs has been not fully addressed: most of the devices are driven at a constant speed, which does not take into account changes in patient physiologic demands [3, 4].
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Effect of Continuous-Flow Left Ventricular Assist Device on Cardiac Function: Simulation Study With a Biventricular Computer Model
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Wang, Y, Ferreira, A, Keller, BB, Simon, M, & Antaki, JF. "Effect of Continuous-Flow Left Ventricular Assist Device on Cardiac Function: Simulation Study With a Biventricular Computer Model." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 521-522. ASME. https://doi.org/10.1115/SBC2011-53784
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