Laminar and turbulent numerical simulations of steady flow in an aneurysm model were carried out over Reynolds numbers ranging from 300 to 3600. The numerical simulations are validated with Digital Particle Image Velocimetry (DPIV) measurements, and used to study the fluid dynamic mechanisms that characterize aneurysm deterioration, by correlating them to in vitro blood platelet deposition results. It is shown that the recirculation zone formed inside the aneurysm cavity creates conditions that promote thrombus formation and the viability of rupture. Wall shear stress values in the recirculation zone are around one order of magnitude less than in the entrance zone. The point of reattachment at the distal end of the aneurysm is characterized by a pronounced wall shear stress peak. As the Reynolds number increases in laminar flow, the center of the recirculation region migrates toward the distal end of the aneurysm, increasing the pressure at the reattachment point. Under fully turbulent flow conditions (Re = 3600) the recirculation zone inside the aneurysm shrinks considerably. The wall shear stress values are almost one order of magnitude larger than those for the laminar cases. The fluid dynamics mechanisms inferred from the numerical simulation were correlated with measurements of blood platelet deposition, offering useful explanations for the different morphologies of the platelet deposition curves.
Skip Nav Destination
Article navigation
August 1996
Technical Papers
Steady Flow in an Aneurysm Model: Correlation Between Fluid Dynamics and Blood Platelet Deposition
D. Bluestein,
D. Bluestein
Mechanical Engineering Department, Florida International University, Miami, FL 33199
Search for other works by this author on:
L. Niu,
L. Niu
Mechanical Engineering Department, Florida International University, Miami, FL 33199
Search for other works by this author on:
R. T. Schoephoerster,
R. T. Schoephoerster
Mechanical Engineering Department, Florida International University, Miami, FL 33199
Search for other works by this author on:
M. K. Dewanjee
M. K. Dewanjee
Department of Radiology, Division of Nuclear Medicine, University of Miami, Miami, FL 33136
Search for other works by this author on:
D. Bluestein
Mechanical Engineering Department, Florida International University, Miami, FL 33199
L. Niu
Mechanical Engineering Department, Florida International University, Miami, FL 33199
R. T. Schoephoerster
Mechanical Engineering Department, Florida International University, Miami, FL 33199
M. K. Dewanjee
Department of Radiology, Division of Nuclear Medicine, University of Miami, Miami, FL 33136
J Biomech Eng. Aug 1996, 118(3): 280-286 (7 pages)
Published Online: August 1, 1996
Article history
Received:
September 20, 1994
Revised:
June 14, 1995
Online:
October 30, 2007
Citation
Bluestein, D., Niu, L., Schoephoerster, R. T., and Dewanjee, M. K. (August 1, 1996). "Steady Flow in an Aneurysm Model: Correlation Between Fluid Dynamics and Blood Platelet Deposition." ASME. J Biomech Eng. August 1996; 118(3): 280–286. https://doi.org/10.1115/1.2796008
Download citation file:
Get Email Alerts
Related Articles
In Vitro Thrombogenicity Testing of Biomaterials in a Dynamic Flow Loop: Effects of Length and Quantity of Test Samples
J. Med. Devices (September,2023)
A Quantitative Comparison of Mechanical Blood Damage Parameters in Rotary Ventricular Assist Devices: Shear Stress, Exposure Time and Hemolysis Index
J Biomech Eng (August,2012)
Numerical Study of Shear-Induced Thrombus Formation Over Aterial Stent Struts
J. Med. Devices (June,2009)
Tortuosity Triggers Platelet Activation and Thrombus Formation in Microvessels
J Biomech Eng (December,2011)
Related Proceedings Papers
Related Chapters
Introduction
Mechanical Blood Trauma in Circulatory-Assist Devices
Fluid Mechanics
Engineering Practice with Oilfield and Drilling Applications
Two Advanced Methods
Applications of Mathematical Heat Transfer and Fluid Flow Models in Engineering and Medicine