The left ventricular ejection fraction (LVEF) is an important clinical indicator of the cardiac function and long-term outcome for patients with coronary artery disease. A biomechanical model of the left ventricle was developed to quantitatively predict post-revascularization LVEF based on noninvasive magnetic resonance imaging. The myocardium was categorized into normal, hibernating, and infarcted regions from the ventricular short-axis images. Assuming that hibernating tissue would potentially regain contractility after revascularization, the expected maximum post-revascularization LVEF was calculated for four patients with chronic left ventricular dysfunction. The predictions were within three ejection fraction points of the follow-up LVEFs. This model may be useful to estimate the outcome and efficacy of revascularization plans.

Issue Section:
Technical Papers
Keywords:
Cardiac Function, Myocardial Ischemia, Hibernating Myocardium, Coronary Artery Disease, cardiology, biomedical MRI, diseases, blood vessels, biomechanics
Topics:
Coronary arteries, Diseases, Magnetic resonance, Magnetic resonance imaging, Myocardium, Biomechanics, Imaging
1.
Bonow
,
R. O.
,
1995
, “
The hibernating myocardium: implications for management of congestive heart failure
,”
Am. J. Cardiol.
,
75
, pp.
17A–25A
17A–25A
.
2.
Iskandrian
,
A. S.
,
Heo
,
J.
, and
Schelbert
,
H. R.
,
1996
, “
Myocardial Viability: Methods of Assessment and Clinical Relevance
,”
Am. Heart J.
,
132
(
6
), pp.
1226
–
1235
.
3.
Baer
,
F. M.
,
Voth
,
E.
,
Schneider
,
C. A.
,
Theissen
,
P.
,
Schicha
,
H.
, and
Sechtem
,
U.
,
1995
, “
Comparison of Low-Dose Dobutamine-Gradient-Echo Magnetic Resonance Imaging and Positron Emission Tomography With [18F]Fluorodeoxyglucose in Patients With Chronic Coronary Artery Disease. A Functional and Morphological Approach to the Detection of Residual Myocardial Viability
,”
Circulation
,
91
(
4
), pp.
1006
–
1015
.
4.
Pettigrew
,
R. I.
, and
Cecil
,
M. P.
,
1993
, “
Basic Cardiovascular Magnetic Resonance Imaging Techniques
,”
Coron. Artery Dis.
,
4
(
4
), pp.
318
–
327
.
5.
Pagano
,
D.
,
Bonser
,
R. S.
,
Townsend
,
J. N.
,
Ordoubadi
,
F.
,
Lorenzoni
,
R.
, and
Camici
,
P. G.
,
1998
, “
Predictive Value of Dobutamine Echocardiography and Positron Emission Tomography in Identifying Hibernating Myocardium in Patients With Postischaemic Heart Failure
,”
Heart
,
79
(
3
), pp.
281
–
288
.
6.
Pasquet
,
A.
,
Lauer
,
M. S.
,
Williams
,
M. J.
,
Secknus
,
M. A.
,
Lytle
,
B.
, and
Marwick
,
T. H.
,
2000
, “
Prediction of Global Left Ventricular Function After Bypass Surgery in Patients With Severe Left Ventricular Dysfunction. Impact of Pre-operative Myocardial Function, Perfusion, and Metabolism,” with editorial comment
,
Eur. Heart J.
,
21
(
2
), pp.
125
–
136
.
7.
Perez-Balino
,
N. A.
,
Masoli
,
O. H.
,
Meretta
,
A. H.
,
Rodriguez
,
A.
,
Cragnolino
,
D. E.
,
Perrone
,
S.
,
Boullon
,
F.
,
Mele
,
E.
,
Palacios
,
I.
, and
Brown
,
K. A.
,
1996
, “
Amrinone Stimulation Test: Ability to Predict Improvement in Left Ventricular Ejection Fraction After Coronary Bypass Surgery in Patients With Poor Baseline Left Ventricular Function
,”
J. Am. Coll. Cardiol.
,
28
(
6
), pp.
1488
–
1492
.
8.
Fung, Y. C., 1993, Biomechanics: Mechanical Properties of Living Tissues, Springer-Verlag, New York, 2nd edition, Chapter 10.
Copyright © 2002
 by ASME
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