The stress-strain relationship is determined by the inherent mechanical properties of the intestinal wall, the geometric configurations, the loading conditions and the zero-stress state of the segment. The purpose of this project was to provide morphometric and biomechanical data for rat duodenum, jejunum and ileum. The circumferential strains were referenced to the zero-stress state. Large morphometric variations were found along the small intestine with an increase in the outer circumferential length and luminal area and a decrease in wall thickness in distal direction. The serosal residual strain was tensile and decreased in distal direction The mucosal residual strain was compressive and the absolute value decreased in distal direction The stress-strain experiments showed that the duodenum was stiffest. All segments were stiffest in longitudinal direction In conclusion, axial variation in morphometric and biomechanical properties was found in the small intestine. The zero-stress state must be considered in future biomechanical studies in the gastrointestinal tract.
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April 2003
Technical Papers
Morphology and Stress-Strain Properties Along the Small Intestine in the Rat
Yanling Dou,
Yanling Dou
Institute of Experimental Clinical Research, Aarhus University, Denmark
Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, P.R. China
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Jingbo Zhao,
Jingbo Zhao
Institute of Experimental Clinical Research, Aarhus University, Denmark
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Hans Gregersen
Hans Gregersen
Institute of Experimental Clinical Research, Aarhus University, Denmark
Biomechanics Lab, Center for Sensory-Motor Interaction, Aalborg University and Department of Surgery A, Aalborg Hospital, Denmark
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Yanling Dou
Institute of Experimental Clinical Research, Aarhus University, Denmark
Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, P.R. China
Jingbo Zhao
Institute of Experimental Clinical Research, Aarhus University, Denmark
Hans Gregersen
Institute of Experimental Clinical Research, Aarhus University, Denmark
Biomechanics Lab, Center for Sensory-Motor Interaction, Aalborg University and Department of Surgery A, Aalborg Hospital, Denmark
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received October 1999; revised manuscript received October 2002. Associate Editor: V. T. Turitto.
J Biomech Eng. Apr 2003, 125(2): 266-273 (8 pages)
Published Online: April 9, 2003
Article history
Received:
October 1, 1999
Revised:
October 1, 2002
Online:
April 9, 2003
Citation
Dou, Y., Zhao, J., and Gregersen, H. (April 9, 2003). "Morphology and Stress-Strain Properties Along the Small Intestine in the Rat ." ASME. J Biomech Eng. April 2003; 125(2): 266–273. https://doi.org/10.1115/1.1560140
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