The recording of neural ensembles in awake, behaving rats has been an extremely successful experimental paradigm, providing demonstrable scientific advances. Dynamic control of the position of the implanted electrodes is of key importance as mobile electrodes provide a better signal-to-noise ratio and a better cell/electrode yield than nonmobile electrodes. Here we describe the use of low cost, soon to be commercially available dc motors to successfully control the depth of electrodes. The prototype designed is approximately in diameter and in length and weighed about . This paper presents the results of linear displacements of electrodes achievable with this motorized microdrive.
Issue Section:
Technical Briefs
1.
Buzsáki
, G.
, 2004, “Large-Scale Recording of Neuronal Ensembles
,” Nat. Neurosci.
1097-6256, 7
, No. 5
, pp. 446
–451
.2.
Wilson
, M. A.
, and McNaughton
, B. L.
, 1993, “Dynamics of the Hippocampal Ensemble Code for Space
,” Science
0036-8075, 261
, pp. 1055
–1058
.3.
Zhang
, K.
, Ginzburg
, I.
, McNaughton
, B. L.
, and Sejnowski
, T. J.
, 1998, “Interpreting Neuronal Population Activity by Reconstruction: Unified Framework With Application to Hippocampal Place Cells
,” J. Neurophysiol.
0022-3077, 79
, pp. 1017
–1044
.4.
Laubach
, M.
, Wessberg
, J.
, and Nicolelis
, M. A. L.
, 2000, “Cortical Ensemble Activity Increasingly Predicts Behavior Outcomes During Learning of a Motor Task
,” Nature (London)
0028-0836, 405
, pp. 567
–571
.5.
Johnson
, A.
, Seeland
, K. D.
, and Redish
, A. D.
, 2005, “Reconstruction of the Postsubiculum Head Direction Signal From Neural Ensembles
,” Hippocampus
1050-9631, 15
, pp. 86
–96
.6.
Korshunov
, V. A.
, 1995, “Miniature Microdrive for Extra Cellular Recording of Neuronal Activity in Freely Moving Animals
,” J. Neurosci. Methods
0165-0270, 57
, pp. 77
–80
.7.
Schmitzer-Torbert
, N. C.
, and Redish
, A. D.
, 2004, “Neuronal Activity in the Rodent Dorsal Striatum in Sequential Navigation: Separation of Spatial and Reward Responses on the Multiple T Task
,” J. Neurophysiol.
0022-3077, 91
, No. 5
, pp. 2259
–2272
.8.
Henze
, D. A.
, Borhegyi
, Z.
, Csicsivari
, J.
, Mamiya
, A.
, Harris
, K. D.
, and Buzsaki
, G.
, 2000, “Intracellular Features Predicted by Extracellular Recordings in the Hippocampus in vivo
,” J. Neurophysiol.
0022-3077, 84
, No. 1
, pp. 390
–400
.9.
Fee
, M. S.
, and Leonardo
, A.
, 2001, “Miniature Motorized Microdrive and Commutator System for Chronic Neural Recording in Small Animals
,” J. Neurosci. Methods
0165-0270, 112
, pp. 83
–94
.10.
Cham
, Jorge G.
, Branchaud
, Edward A.
, Nenadic
, Zoran
, Greger
, Bradley
, Andersen
, Richard A.
, and Burdick
, Joel W.
, 2004, “A Semi-Chronic Motorized Microdrive and Control Algorithm for Autonomously Isolating and Maintaining Optimal Extracellular Action Potentials
,” J. Neurophysiol.
0022-3077, 93
, pp. 570
–579
.11.
Amaral
, D. G.
, and Witter
, M. P.
, 1989, “The Three-Dimensional Organization of the Hippocampal Formation: A Review of Anatomical Data
,” Neuroscience
0306-4522, 31
, No. 3
, pp. 571
–591
.12.
Reitbock
, H.
, Adamczak
, W.
, Eckhorn
, R.
, Muth
, P.
, Thielmann
, R.
, and Thomas
, U.
, 1981, “Multiple Single-Unit Recording. Design and Test of a 19-Channel Micromanipulator and Appropriate Fiber Electrodes
,” Neurosci. Lett.
0304-3940, 7
, p. 181
.13.
Redish
, A. D.
, 1999, Beyond the Cognitive Map: From Place Cells to Episodic Memory
, MIT Press
, Cambridge, MA.14.
Redish
, A. D.
, and Schmitzer-Torbert
, N. C.
, 2004, MClust Spike Sorting Toolbox, version 3.3. http://www.cbc.umn.edu/~redish/mclusthttp://www.cbc.umn.edu/~redish/mclust15.
Schmitzer-Torber
, N. C.
, Jackson
, J.
, Henze
, D.
, Harris
, K.
, and Redish
, A. D.
, 2005, “Quantitative Measures of Cluster Quality for Use in Extracellular Recording
,” Neuroscience
0306-4522, 131
, pp. 1
–11
.Copyright © 2005
by American Society of Mechanical Engineers
You do not currently have access to this content.
