Electroporation is an approach used to enhance the transport of large molecules to the cell cytosol in which a targeted tissue region is exposed to a series of electric pulses. The cell membrane, which normally acts as a barrier to large molecule transport into the cell interior, is temporarily destabilized due to the development of pores in the cell membrane. Consequently, agents that are ordinarily unable enter the cell are able to pass through the cell membrane. Of possible concern when exposing biological tissue to an electric field is thermal tissue damage associated with joule heating. This paper explores the thermal effects of various geometric, biological, and electroporation pulse parameters including the blood vessel presence and size, plate electrode configuration, and pulse duration and frequency. A three-dimensional transient finite volume model of in vivo parallel plate electroporation of liver tissue is used to develop a better understanding of the underlying relationships between the physical parameters involved with tissue electroporation and resulting thermal damage potential.
Skip Nav Destination
e-mail: smbecker@unity.ncsu.edu
Article navigation
February 2006
Technical Papers
Numerical Modeling of In Vivo Plate Electroporation Thermal Dose Assessment
S. M. Becker,
S. M. Becker
Mechanical and Aerospace Engineering,
e-mail: smbecker@unity.ncsu.edu
North Carolina State University
, Box 7910, Raleigh, NC 27695
Search for other works by this author on:
A. V. Kuznetsov
A. V. Kuznetsov
Mechanical and Aerospace Engineering,
North Carolina State University
, Box 7910, Raleigh, NC 27695
Search for other works by this author on:
S. M. Becker
Mechanical and Aerospace Engineering,
North Carolina State University
, Box 7910, Raleigh, NC 27695e-mail: smbecker@unity.ncsu.edu
A. V. Kuznetsov
Mechanical and Aerospace Engineering,
North Carolina State University
, Box 7910, Raleigh, NC 27695J Biomech Eng. Feb 2006, 128(1): 76-84 (9 pages)
Published Online: August 18, 2005
Article history
Received:
April 4, 2005
Revised:
August 18, 2005
Citation
Becker, S. M., and Kuznetsov, A. V. (August 18, 2005). "Numerical Modeling of In Vivo Plate Electroporation Thermal Dose Assessment." ASME. J Biomech Eng. February 2006; 128(1): 76–84. https://doi.org/10.1115/1.2132375
Download citation file:
Get Email Alerts
Related Articles
Endovascular Nonthermal Irreversible Electroporation: A Finite Element Analysis
J Biomech Eng (March,2010)
Numerical Assessment of Thermal Response Associated With In Vivo Skin Electroporation: The Importance of the Composite Skin model
J Biomech Eng (June,2007)
High-Density Transcranial DC Stimulation (HD-tDCS): Targeting Software
J. Med. Devices (June,2009)
Radio-Frequency Ablation in a Realistic Reconstructed Hepatic Tissue
J Biomech Eng (June,2007)
Related Proceedings Papers
Related Chapters
Role of Artificial Intelligence in Hepatitis B Diagnosis
International Conference on Mechanical and Electrical Technology, 3rd, (ICMET-China 2011), Volumes 1–3
The Complementary DNA Segment Cloning and Bioinformatics Analysis of INTS2 Gene in Goose
International Conference on Computer Technology and Development, 3rd (ICCTD 2011)
Based on Blood Vessel Edge Feature Fundus Fluorescein Angiography Image Splicing
International Conference on Instrumentation, Measurement, Circuits and Systems (ICIMCS 2011)