The transport and deposition of nanoparticles, i.e., –, or equivalent vapors, in the human nasal cavities is of interest to engineers, scientists, air-pollution regulators, and healthcare officials alike. Tiny ultrafine particles, i.e., , are of special interest because they are most rapidly absorbed and hence have an elevated toxic or therapeutic impact when compared to larger particles. Assuming transient laminar 3-D incompressible flow in a representative human nasal cavity, the cyclic airflow pattern as well as local and overall nanoparticle depositions were computationally simulated and analyzed. The focus was on transient effects during inhalation/exhalation as compared to the steady-state assumption typically invoked. Then, an equation for a matching steady-state inhalation flow rate was developed that generates the same deposition results as cyclic inhalation. Of special interest is the olfactory region where the narrow channel surfaces receive only about one-half of a percent of the inhaled nanoparticles because the airflow bypasses these recesses located in the superior-most portions in the geometrically complex nasal cavities.
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e-mail: ck@eos.ncsu.edu
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October 2006
Technical Papers
Laminar Airflow and Nanoparticle or Vapor Deposition in a Human Nasal Cavity Model
H. Shi,
H. Shi
Department of Mechanical and Aerospace Engineering,
North Carolina State University
, Raleigh, NC 27695-7910
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C. Kleinstreuer,
C. Kleinstreuer
Department of Mechanical and Aerospace Engineering and Department of Biomedical Engineering,
e-mail: ck@eos.ncsu.edu
North Carolina State University
, Raleigh, NC 27695-7910
Search for other works by this author on:
Z. Zhang
Z. Zhang
Department of Mechanical and Aerospace Engineering,
North Carolina State University
, Raleigh, NC 27695-7910
Search for other works by this author on:
H. Shi
Department of Mechanical and Aerospace Engineering,
North Carolina State University
, Raleigh, NC 27695-7910
C. Kleinstreuer
Department of Mechanical and Aerospace Engineering and Department of Biomedical Engineering,
North Carolina State University
, Raleigh, NC 27695-7910e-mail: ck@eos.ncsu.edu
Z. Zhang
Department of Mechanical and Aerospace Engineering,
North Carolina State University
, Raleigh, NC 27695-7910J Biomech Eng. Oct 2006, 128(5): 697-706 (10 pages)
Published Online: March 6, 2006
Article history
Received:
May 25, 2005
Revised:
March 6, 2006
Citation
Shi, H., Kleinstreuer, C., and Zhang, Z. (March 6, 2006). "Laminar Airflow and Nanoparticle or Vapor Deposition in a Human Nasal Cavity Model." ASME. J Biomech Eng. October 2006; 128(5): 697–706. https://doi.org/10.1115/1.2244574
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