The presence of bacterial biofilms is detrimental in a wide range of healthcare situations especially wound healing. Physical debridement of biofilms is a method widely used to remove them. This study evaluates the use of microfluidic jet impingement to debride biofilms. In this case, a biofilm is treated as a saturated porous medium also having linear elastic properties. A numerical modeling approach is used to calculate the von Mises stress distribution within a porous medium under fluid-structure interaction (FSI) loading to determine the initial rupture of the biofilm structure. The segregated model first simulates the flow field to obtain the FSI interface loading along the fluid-solid interface and body force loading within the porous medium. A stress-strain model is consequently used to calculate the von Mises stress distribution to obtain the biofilm deformation. Under a vertical jet, 60% of the deformation of the porous medium can be accounted for by treating the medium as if it was an impermeable solid. However, the maximum deformation in the porous medium corresponds to the point of maximum shear stress which is a different position in the porous medium than that of the maximum normal stress in an impermeable solid. The study shows that a jet nozzle of 500 μm internal diameter (ID) with flow of Reynolds number (Re) of 200 can remove the majority of biofilm species.
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e-mail: lzheng1@binghamton.edu
e-mail: farnam@binghamton.edu
e-mail: homentco@binghamton.edu
e-mail: bahgat@binghamton.edu
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A Porous Elastic Model for Bacterial Biofilms: Application to the Simulation of Deformation of Bacterial Biofilms Under Microfluidic Jet Impingement
Leo Y. Zheng,
Leo Y. Zheng
Mechanical Engineering Department,
e-mail: lzheng1@binghamton.edu
Binghamton University-SUNY
, Binghamton, NY 13902
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Dylan S. Farnam,
Dylan S. Farnam
Mechanical Engineering Department,
e-mail: farnam@binghamton.edu
Binghamton University-SUNY
, Binghamton, NY 13902
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Dorel Homentcovschi,
Dorel Homentcovschi
Mechanical Engineering Department,
e-mail: homentco@binghamton.edu
Binghamton University-SUNY
, Binghamton, NY 13902
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Bahgat G. Sammakia
Bahgat G. Sammakia
Mechanical Engineering Department,
e-mail: bahgat@binghamton.edu
Binghamton University-SUNY
, Binghamton, NY 13902
Search for other works by this author on:
Leo Y. Zheng
Mechanical Engineering Department,
Binghamton University-SUNY
, Binghamton, NY 13902e-mail: lzheng1@binghamton.edu
Dylan S. Farnam
Mechanical Engineering Department,
Binghamton University-SUNY
, Binghamton, NY 13902e-mail: farnam@binghamton.edu
Dorel Homentcovschi
Mechanical Engineering Department,
Binghamton University-SUNY
, Binghamton, NY 13902e-mail: homentco@binghamton.edu
Bahgat G. Sammakia
Mechanical Engineering Department,
Binghamton University-SUNY
, Binghamton, NY 13902e-mail: bahgat@binghamton.edu
J Biomech Eng. May 2012, 134(5): 051003 (7 pages)
Published Online: May 25, 2012
Article history
Received:
September 30, 2011
Revised:
March 28, 2012
Posted:
May 1, 2012
Published:
May 25, 2012
Online:
May 25, 2012
Citation
Zheng, L. Y., Farnam, D. S., Homentcovschi, D., and Sammakia, B. G. (May 25, 2012). "A Porous Elastic Model for Bacterial Biofilms: Application to the Simulation of Deformation of Bacterial Biofilms Under Microfluidic Jet Impingement." ASME. J Biomech Eng. May 2012; 134(5): 051003. https://doi.org/10.1115/1.4006683
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