Most computational models of abdominal aortic aneurysms address either the hemodynamics within the lesion or the mechanics of the wall. More recently, however, some models have appropriately begun to account for the evolving mechanics of the wall in response to the changing hemodynamic loads. Collectively, this large body of work has provided tremendous insight into this life-threatening condition and has provided important guidance for current research. Nevertheless, there has yet to be a comprehensive model that addresses the mechanobiology, biochemistry, and biomechanics of thrombus-laden abdominal aortic aneurysms. That is, there is a pressing need to include effects of the hemodynamics on both the development of the nearly ubiquitous intraluminal thrombus and the evolving mechanics of the wall, which depends in part on biochemical effects of the adjacent thrombus. Indeed, there is increasing evidence that intraluminal thrombus in abdominal aortic aneurysms is biologically active and should not be treated as homogeneous inert material. In this review paper, we bring together diverse findings from the literature to encourage next generation models that account for the biochemomechanics of growth and remodeling in patient-specific, thrombus-laden abdominal aortic aneurysms.
Biochemomechanics of Intraluminal Thrombus in Abdominal Aortic Aneurysms
Contributed by the Bioengineering Division of ASME for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received November 13, 2012; final manuscript received January 14, 2013; accepted manuscript posted January 18, 2013; published online February 7, 2013. Editor: Victor H. Barocas.
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Wilson, J. S., Virag, L., Di Achille, P., Karšaj, I., and Humphrey, J. D. (February 7, 2013). "Biochemomechanics of Intraluminal Thrombus in Abdominal Aortic Aneurysms." ASME. J Biomech Eng. February 2013; 135(2): 021011. https://doi.org/10.1115/1.4023437
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