Pulsatile mock loop systems are largely used to investigate the cardiovascular system in vitro. They consist of a pump, which replicates the heart, coupled with a lumped-parameter hydraulic afterload, which simulates vasculature. An accurate dimensioning of components is required for a reliable mimicking of the physiopathological behavior of the system. However, it is not possible to create a component for the afterload inertance, and inertance contributions are present in the entire circuit. Hence, in the literature, inertance is neglected or qualitatively evaluated. In this paper, we propose two quantitative methods (Maximum-likelihood estimation (MLE) and Bayesian estimation) for estimating afterload inertance based on observed pressure and flow waveforms. These methods are also applied to a real mock loop system. Results show that the system has an inertance comparable with the literature reference value of the entire systemic circulation, and that the expected variations over inlet average flow and pulse frequency are in general confirmed. Comparing the methods, the Bayesian approach results in higher and more stable estimations than the classical MLE.
Inertance Estimation in a Lumped-Parameter Hydraulic Simulator of Human Circulation
Italian National Research Council (CNR),
Contributed by the Bioengineering Division of ASME for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received January 4, 2013; final manuscript received March 22, 2013; accepted manuscript posted April 4, 2013; published online May 10, 2013. Assoc. Editor: Tim David.
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Lanzarone, E., and Ruggeri, F. (May 10, 2013). "Inertance Estimation in a Lumped-Parameter Hydraulic Simulator of Human Circulation." ASME. J Biomech Eng. June 2013; 135(6): 061012. https://doi.org/10.1115/1.4024138
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