The aim of this research was to analyze the impact of the human body position changes caused by propelling a wheelchair with the pushrim propulsion on the value of motion resistance force. The discussed research works are in progress; therefore, the presented results should be treated as preliminary. The research was carried out in the group of six volunteers propelling a wheelchair of which frame was inclined, in respect to the horizontal plane, under the angle of 0 deg, 7 deg, and 14 deg. The area of the position variability of the human body center of gravity (COG) and the coefficients of wheelchair rolling resistance have been determined. Based on the measurements conducted, rolling resistance force FT and motion resistance force FR have been defined for three values of frame inclination angle. The determined force of rolling resistance Ft depended on the location of the COG of the human body and the value of the coefficients of rolling resistance of the front and rear wheels of a wheelchair. This force was a component of the resistance to motion FR, which also took into account the influence of gravity resulting from the inclination of the wheelchair on an inclined plane. For the tested inclination angles relative to the horizontal plane, the rolling resistance force ranged from 9.82 N to 22.81 N. Analyzing the variability of the rolling resistance force FT, it was found that for the final phase of the driving motion, it increased by 36% for the inclination angle of 0 deg and 43% for the inclination angle of 7 deg. Its increase was 48% for the inclination angle of 14 deg in relation to the human body position for the beginning of the driving motion. In the case of measuring the value of the resistance to motion FR, it was observed that, depending on the angle of the incline of the wheelchair, it ranged from 14.69 N to 256.33 N. The measurements conducted enabled the derivation of an analytical model for determining rolling resistance force depending on the position of the human body COG and the wheelchair inclination angle. The conducted research demonstrated the impact of the COG position on the changes of motion resistance force, thus expanding the state of knowledge, introducing a new parameter which, like a surface type and wheel type, affects motion resistances.