...Taly P. Appelman; Joseph Mizrahi; Dror Seliktar Mechanically induced cell deformations have been shown to influence chondrocyte response in 3D culture. However, the relationship between the mechanical stimulation and cell response is not yet fully understood. In this study a finite element model...

..., and thus may aid in identifying differentiated hESCs, which are most suitable for tissue engineering. This study examined the viscoelastic properties of single undifferentiated hESCs, chondrogenically differentiated hESC subpopulations, mesenchymal stem cells (MSCs), and articular chondrocytes (ACs). hESC...

... boundary-elements methods biological techniques physiological models boundary integral equations Cartilage Osteoarthritis Cell Mechanics Chondrocyte Mechanotransduction Articular cartilage serves as the resilient load-bearing surface at the ends of long bones in diarthroidal joints...

... aspiration creep test with ramp time t * = 0.1 s and ramp pressure p * / E = 0.8 is simulated for the cases a / R = 0.3 , 0.4, 0.5 using mean parameter values for primary chondrocytes. Comparisons to the half-space model indicate that the computational model predicts an aspiration length that is less stiff...