...Meghan E. Kupratis; Uriel Gonzalez; Atia Rahman; David L. Burris; Elise A. Corbin; Christopher Price Healthy articular cartilage is a remarkable bearing material optimized for near-frictionless joint articulation. Because its limited self-repair capacity renders it susceptible to osteoarthritis (OA...

...@northeastern.edu 1 Corresponding author. e-mail:  s.shefelbine@northeastern.edu 14 06 2022 07 11 2022 09 12 2022 articular cartilage biphasic poro-viscoelastic material model cartilage degeneration indentation Articular cartilage is a hyaline type of cartilage...

...Peter A. Torzilli; Samie N. Allen Early stage osteoarthritis is characterized by disruption of the superficial zone (SZ) of articular cartilage, including collagen damage and proteoglycan loss, resulting in “mechanical softening” of the extracellular matrix (ECM). The role of the SZ in controlling...

... of the animals and the exact time from sacrifice to testing. The different genetic backgrounds of the animals likely also resulted in variations of the outcome variables. Furthermore, stiffness of articular cartilage differs as a function of cartilage depth. Therefore, cartilage deformations are expected...

...Benjamin C. Marchi; Ellen M. Arruda; Rhima M. Coleman Articular cartilage focal defects are common soft tissue injuries potentially linked to osteoarthritis (OA) development. Although several defect characteristics likely contribute to osteoarthritis, their relationship to local tissue deformation...

... frozen for seven days and then measured. Seven indentations (various normalized displacements) were implemented with an indention rate of 0.1 mm/s. Solid phase aggregate modulus (E s ), hyperelastic material constant ( α ), and fluid load fraction (F′) of equine articular cartilage were assessed using...

...Chris D. DiDomenico; Lawrence J. Bonassar Molecular transport of osteoarthritis (OA) therapeutics within articular cartilage is influenced by many factors, such as solute charge, that have yet to be fully understood. This study characterizes how solute charge influences local diffusion...

..., 2014; published online May 6, 2014. Assoc. Editor: James C. Iatridis. Proteoglycan content was found to be more directly related to articular cartilage strain than other parameters (Fig. 6 ). The precise relationship between strain change and articular cartilage proteoglycan content remains...

.... This study investigated the acute biomechanical effects of bipolar RFE treatment on human chondromalacic cartilage. Articular cartilage specimens were extracted (n = 50) from femoral condyle samples of patients undergoing total knee arthroplasty. Chondromalacia was graded with the Outerbridge classification...

... to differentially modulate the growth of immature bovine articular cartilage. IGF-1 stimulates expansive growth yet decreases compressive moduli and increases compressive Poisson’s ratios, whereas TGF-β1 maintains tissue size, increases compressive moduli, and decreases compressive Poisson’s ratios. The current...

...Patrick A. Smyth; Rebecca E. Rifkin; Robert L. Jackson; R. Reid Hanson The naturally occurring structure of articular cartilage has proven to be an effective means for the facilitation of motion and load support in equine and other animal joints. For this reason, cartilage has been extensively...

...Nicolas V. Jaumard; William C. Welch; Beth A. Winkelstein The facet joint is a crucial anatomic region of the spine owing to its biomechanical role in facilitating articulation of the vertebrae of the spinal column. It is a diarthrodial joint with opposing articular cartilage surfaces that provide...

... of subject-specific models of the patellofemoral joint and evaluate trade-offs in analysis time and accuracy with fully deformable and rigid body articular cartilage representations. Finite element models of eight subjects were used to tune a pressure-overclosure relationship during a simulated deep flexion...

... 17 10 2009 21 12 2009 03 02 2010 biological fluid dynamics biological tissues finite element analysis friction lubrication mechanical contact physiological models wear articular cartilage biphasic contact mechanics finite element contact dependent flow...

... of reproducing the deformation behavior of human articular cartilage in the physiological loading domain, as demonstrated by the good agreement between the experiment and numerical results ( R 2 = 0.95 ± 0.03 , mean ± standard deviation of force-time response for 23 indentation tests). To address validation...

... 05 2009 biochemistry biomechanics cellular biophysics tissue engineering viscoelasticity cellular mechanics biomechanics chondrocyte articular cartilage unconfined cytocompression The biomechanical properties of single cells may significantly influence tissue development...

... engineering cellular biophysics prosthetics tissue engineering tension compression tissue culture strain analysis articular cartilage superficial tangential zone Tissue engineering is essential in the field of reparative medicine to replace damaged tissues that do not regenerate...

...C. J. Moger; K. P. Arkill; R. Barrett; P. Bleuet; R. E. Ellis; E. M. Green; C. P. Winlove An investigation of collagen fiber reorientation, as well as fluid and matrix movement of equine articular cartilage and subchondral bone under compressive mechanical loads, was undertaken using small angle X...

...Holly A. Leddy; Susan E. Christensen; Farshid Guilak Chondrocytes, the cells in articular cartilage, are enclosed within a pericellular matrix (PCM) whose composition and structure differ from those of the extracellular matrix (ECM). Since the PCM surrounds each cell, molecules that interact...

...Roman M. Natoli; Kyriacos A. Athanasiou Prior joint injury predisposes an individual to developing post-traumatic osteoarthritis, for which there is presently no disease modifying treatment. In this condition, articular cartilage degenerates due to cell death and matrix breakdown, resulting...