... to a true appreciation of how vascular cells maintain, remodel, or repair the arteries that are fundamental to cardiovascular properties and function. Invented in the early 1980s at IBM, atomic force microscopy (AFM) uses a laser to detect small deflections of a cantilever probe as it interacts...

... are unclear. We developed a methodology for collapsing giant unilamellar vesicles (GUVs) into supported bilayers in a way that keeps membrane nanodomains stable and enables their imaging. We used a combination of fluorescence and atomic force microscopy (AFM) of this system to uncover how a surprising phase...

... in their elasticities. In this study, we determined the Young’s modulus of hESCs by atomic force microscopy using a pyramidal tip. Using this method we are able to take point measurements of elasticity at multiple locations on a single cell, allowing local variations due to cell structure to be identified. We found...

... Mechanisms in the Rat ,” Stapp Car Crash Journal , 50 , pp. 583 – 600 . 1532-8546 Costa , K. D. , and Yin , F. C. P. , 1999 , “ Analysis of Indentation: Implications for Measuring Mechanical Properties With Atomic Force Microscopy ,” ASME J. Biomech. Eng. 0148-0731 , 121 ( 5 ), pp...

...S. Tripathy; E. J. Berger Relaxation indentation experiments using atomic force microscopy (AFM) are used to obtain viscoelastic material properties of soft samples. The quasilinear viscoelastic (QLV) model formulated by Fung ( 1972, “Stress Strain History Relations of Soft Tissues in Simple...

...Jason D. Hemmer; Jiro Nagatomi; Scott T. Wood; Alexey A. Vertegel; Delphine Dean; Martine LaBerge A number of recent studies have demonstrated the effectiveness of atomic force microscopy (AFM) for characterization of cellular stress-relaxation behavior. However, this technique’s recent development...

...David C. Lin; Emilios K. Dimitriadis; Ferenc Horkay In the first of this two-part discourse on the extraction of elastic properties from atomic force microscopy (AFM) data, a scheme for automating the analysis of force-distance curves was introduced and experimentally validated for the Hertzian...

... hypothesis. The validation of the constitutive model using finite element analysis on atomic force microscopy (AFM) and magnetic twisting cytometry (MTC) has been carried out and is found to yield good correlation with reported experimental results. It is observed from the study that as the volume fraction...

.... Error in force as a function of the ratio of equivalent deflection to tip radius 12 06 2006 15 11 2006 tissue engineering cellular biophysics indentation biomechanics biomedical materials polymers gels elasticity atomic force microscopy Young's modulus mechanical testing...

.... , Kobayashi , K. , and Hoshino , T. , 1997 , “ Atomic Force Microscopy of Collagen Molecules. Surface Morphology of Segment-Long-Spacing (SLS) Crystallites of Collagen ,” J. Electron Microsc. 0022-0744 , 46 ( 4 ), pp. 321 – 326 . Paige , M. F. , Rainey , J. K. , and Goh , M. C...

...Kevin D. Costa; Alan J. Sim; Frank C-P. Yin Detailed measurements of cell material properties are required for understanding how cells respond to their mechanical environment. Atomic force microscopy (AFM) is an increasingly popular measurement technique that uniquely combines subcellular...

... creep biomechanics cellular biophysics indentation viscosity biological techniques atomic force microscopy Biomechanics Cartilage Cellular Engineering Mechanotransduction Punch Problem Single Cell Mechanics Standard Linear Solid Tissue Engineering Viscoelasticity Interest...