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Keywords: lung
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Journal Articles
Article Type: Technical Briefs
J Biomech Eng. July 2014, 136(7): 074504.
Paper No: BIO-13-1509
Published Online: May 29, 2014
... stiffness and echo intensity. An analogous relationship between volume-dependent pressure changes and echo intensity changes in inflating lungs would indicate a correlation between lung compliance and echo intensity. Lung compliance is an important metric to diagnose pathologies which affect lung tissue...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. December 2011, 133(12): 124502.
Published Online: December 21, 2011
... of electrical charges, sizes, concentrations of the particles have been investigated. In this paper, the temperature effect on the cellular uptake of Quantum Dots (QDs) is studied experimentally. QDs are incubated with the SPCA-1 human lung tumor cells, and the nanoparticles on the cell membrane and inside...
Journal Articles
Article Type: Research Papers
J Biomech Eng. November 2011, 133(11): 111005.
Published Online: November 29, 2011
... of the acinar duct would result in irreversible acinar flow fields, which might be important mechanistic contributors to aerosol mixing and deposition deep in the lung. aerosols elasticity lung muscle pneumodynamics stress-strain relations surface tension surfactants lung surfactant smooth...
Journal Articles
Article Type: Research Papers
J Biomech Eng. June 2011, 133(6): 061004.
Published Online: June 21, 2011
...Emily J. Berg; Risa J. Robinson Emphysema is a progressive lung disease that involves permanent destruction of the alveolar walls. Fluid mechanics in the pulmonary region and how they are altered with the presence of emphysema are not well understood. Much of our understanding of the flow fields...
Journal Articles
Article Type: Research Papers
J Biomech Eng. January 2011, 133(1): 011003.
Published Online: December 22, 2010
...D. Keith Walters; William H. Luke Computational fluid dynamics (CFD) has emerged as a useful tool for the prediction of airflow and particle transport within the human lung airway. Several published studies have demonstrated the use of Eulerian finite-volume CFD simulations coupled with Lagrangian...
Journal Articles
Article Type: Research Papers
J Biomech Eng. October 2010, 132(10): 101001.
Published Online: September 27, 2010
... explanation for why submicron particles deposit preferentially in the acinar-entrance region. biodiffusion cellular biophysics flow simulation lung molecular biophysics numerical analysis physiological models pipe flow pneumodynamics rotational flow The human lung contains several hundred...
Journal Articles
Article Type: Research Papers
J Biomech Eng. August 2010, 132(8): 081002.
Published Online: June 15, 2010
...Andrew Comerford; Christiane Förster; Wolfgang A. Wall In this paper, we develop structured tree outflow boundary conditions for modeling the airflow in patient specific human lungs. The utilized structured tree is used to represent the nonimageable vessels beyond the 3D domain. The coupling...
Journal Articles
Article Type: Research Papers
J Biomech Eng. May 2010, 132(5): 051009.
Published Online: March 30, 2010
...Sudhaker Chhabra; Ajay K. Prasad The alveoli are the smallest units of the lung that participate in gas exchange. Although gas transport is governed primarily by diffusion due to the small length scales associated with the acinar region ( ∼ 500 μ m ) , the transport and deposition of inhaled...
Journal Articles
Article Type: Research Papers
J Biomech Eng. May 2010, 132(5): 051010.
Published Online: March 30, 2010
...Sudhaker Chhabra; Ajay K. Prasad The acinar region of the human lung comprises about 300 × 10 6 alveoli, which are responsible for gas exchange between the lung and the blood. As discussed in Part I ( Chhabra and Prasad, “Flow and Particle Dispersion in a Pulmonary Alveolus—Part I: Velocity...
Journal Articles
Article Type: Research Papers
J Biomech Eng. March 2010, 132(3): 031012.
Published Online: February 17, 2010
... 17 02 2010 17 02 2010 blood vessels cardiovascular system diseases flow simulation haemodynamics lung paediatrics pneumodynamics surgery Since the introduction of the Fontan procedure ( 1 ), as a palliative surgical repair for patients with various forms of complex...
Journal Articles
Article Type: Research Papers
J Biomech Eng. February 2010, 132(2): 021008.
Published Online: January 29, 2010
...Jessica M. Oakes; Steven Day; Steven J. Weinstein; Risa J. Robinson Particulates that deposit in the acinus region of the lung have the potential to migrate through the alveolar wall and into the blood stream. However, the fluid mechanics governing particle transport to the alveolar wall...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. January 2010, 132(1): 014501.
Published Online: December 8, 2009
.... Modifications first concerned the integration and interfacing of a user-controlled respiratory muscular system including intercostal muscles, scalene muscles, the sternocleidomastoid muscle, and the diaphragm and abdominal wall muscles. Volumetric and pressure measurement procedures for the lungs and both...
Journal Articles
Article Type: Research Papers
J Biomech Eng. March 2009, 131(3): 031010.
Published Online: January 7, 2009
...Josué Sznitman; Thomas Heimsch; Johannes H. Wildhaber; Akira Tsuda; Thomas Rösgen The inhalation of micron-sized aerosols into the lung’s acinar region may be recognized as a possible health risk or a therapeutic tool. In an effort to develop a deeper understanding of the mechanisms responsible...
Journal Articles
Article Type: Research Papers
J Biomech Eng. February 2009, 131(2): 021007.
Published Online: December 10, 2008
...C. Kleinstreuer; Z. Zhang A new methodology for a swift and accurate computer simulation of large segments of the human lung airways is presented. Focusing on a representative tracheobronchial (TB) region, i.e., G0–G15, nano- and micron particle transports have been simulated for Q in = 30 l ∕ min...
Journal Articles
Article Type: Research Papers
J Biomech Eng. January 2009, 131(1): 011010.
Published Online: November 24, 2008
... incorporates key ingredients involved in these maneuvers: the expiratory effort generated by the abdominal and expiratory muscles, the glottis, and the flexibility and compliance of the lung airways. Variations in these allow investigation of the expiratory flows generated by a variety of single cough...
Journal Articles
Article Type: Research Papers
J Biomech Eng. January 2009, 131(1): 011006.
Published Online: November 19, 2008
... theory are then employed to confirm the existence of chaos in the flow in a rigid alveolated duct. 15 06 2007 30 09 2007 19 11 2008 chaos lung mixing pneumodynamics Poincare mapping pulsatile flow The flow in the acinar region of the lung has little inertia...
Journal Articles
Article Type: Research Papers
J Biomech Eng. June 2008, 130(3): 031020.
Published Online: May 9, 2008
... lung normal distribution physiological models pneumodynamics pulmonary pressure-volume curve respiratory system model alveolar recruitment lung injury ARDS Measurements of the quasistatic pressure-volume ( P - V ) curve are aimed at quantitative analyses...
Journal Articles
Article Type: Research Papers
J Biomech Eng. April 2008, 130(2): 021016.
Published Online: April 3, 2008
... of diffusing particles through the carousel effect. 18 12 2006 28 06 2007 03 04 2008 lung physiological models pneumodynamics The purpose of this paper is to explore the effect of recirculation on the transport of diffusing particles in the pulmonary alveolus. Our motivation...
Journal Articles
Article Type: Research Papers
J Biomech Eng. February 2008, 130(1): 011015.
Published Online: February 20, 2008
... the dispersion and transport of therapeutic aerosols in the respiratory tract. A variety of mechanisms may contribute to convective dispersion in the lung; simple axial streaming, augmented dispersion, and steady streaming are investigated in this effort. Flow visualization of a bolus during inhalation...
Journal Articles
Article Type: Research Papers
J Biomech Eng. February 2008, 130(1): 011013.
Published Online: February 11, 2008
... finite element analysis Galerkin method lung mass transfer pneumodynamics mass transfer coefficient bifurcation single path lungs CFD airways expiration When reactive air pollutants are inhaled, a complete breathing cycle consisting of inhalation and exhalation needs to be studied...