This review summarizes computer simulation methodologies of air-particle flow, results of drug-aerosol transport/deposition in models of the human respiratory system, as well as aspects of drug-aerosol targeting and associated inhalation devices. After a brief introduction to drug delivery systems in general, the required modeling and simulation steps for optimal drug-aerosol delivery in the lung are outlined. Starting with medical imaging and file conversion of patient-specific lung-airway morphologies, the air-particle transport phenomena are numerically solved for a representative inhalation flow rate of . Focusing on microspheres and droplets, the complex airflow and particle dynamics, as well as the droplet heat and mass transfer are illustrated. With this foundation as the background, an overview of present inhaler devices is presented, followed by a discussion of the methodology and features of a new smart inhaler system (SIS). With the SIS, inhaled drug-aerosols can be directly delivered to any predetermined target area in the human lung.
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e-mail: ck@eos.ncsu.edu
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Research Papers
Optimal Drug-Aerosol Delivery to Predetermined Lung Sites
Clement Kleinstreuer,
Clement Kleinstreuer
Department of Mechanical and Aerospace Engineering and Department of Biomedical Engineering,
e-mail: ck@eos.ncsu.edu
North Carolina State University
, Raleigh, NC 27695; University of North Carolina
, Chapel Hill, NC 27599
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Zhe Zhang
Zhe Zhang
Department of Mechanical and Aerospace Engineering,
North Carolina State University
, Raleigh, NC 27695
Search for other works by this author on:
Clement Kleinstreuer
Department of Mechanical and Aerospace Engineering and Department of Biomedical Engineering,
North Carolina State University
, Raleigh, NC 27695; University of North Carolina
, Chapel Hill, NC 27599e-mail: ck@eos.ncsu.edu
Zhe Zhang
Department of Mechanical and Aerospace Engineering,
North Carolina State University
, Raleigh, NC 27695J. Heat Transfer. Jan 2011, 133(1): 011002 (12 pages)
Published Online: September 27, 2010
Article history
Received:
March 31, 2010
Revised:
April 28, 2010
Online:
September 27, 2010
Published:
September 27, 2010
Citation
Kleinstreuer, C., and Zhang, Z. (September 27, 2010). "Optimal Drug-Aerosol Delivery to Predetermined Lung Sites." ASME. J. Heat Transfer. January 2011; 133(1): 011002. https://doi.org/10.1115/1.4002224
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