Heat transfer analysis of liquid–liquid Taylor flow in previous studies almost never shows the effect of slug length on heat transfer. The homogenous or single-phase analysis is often the only method available to deal with flow of multicomponents. In this study, a new approach is developed to model the segmented liquid–liquid Taylor flow as two separated systems to present heat transfer enhancement for each component. The effect of internal circulation and boundary layer renewal within the two fluid components is clearly observed. An experimental setup was assembled using an open loop system at miniscale size in which liquid–liquid Taylor flow is heated under a constant wall temperature. Three silicone oils of 1, 3, and 5 cSt were segmented using distilled water at three volume fractions 0.25, 0.5, and 0.75. Finally, heat transfer data of the dimensionless mean wall heat flux shows good agreement with a predictive model proposed in an earlier work by the second author. The results show an impact of the fluid cell dimensions on the rate of heat transfer.