In the present study, replication of flow-through microfilters in the newly developed microfluidic lab-on-a-chip for blood typing by microinjection molding process was experimentally investigated. As a precise replication of the microfilters was required in order to effectively filter out agglutinated red blood cells, the effects of important processing conditions on the replication of the flow-through microfilters were investigated. By using a mold insert fabricated by a nickel electroplating process and a newly designed mold base, microinjection molding experiments were carried out. A three-dimensional solid model reconstruction method was proposed with the help of specific features characterizing the geometry of microfilters, and accordingly, the feature values of the replicated microfilters were measured by a noncontact optical measurement system. So reconstructed solid modeling result was then used to investigate the effects of various processing conditions, such as a flow rate, a mold temperature, and a packing pressure. Amongst the processing conditions investigated in the present study, the flow rate was found to be the most important one.
Replication Quality of Flow-Through Microfilters in Microfluidic Lab-on-a-Chip for Blood Typing by Microinjection Molding
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Lee, B., Hwang, C. J., Kim, D. S., and Kwon, T. H. (March 25, 2008). "Replication Quality of Flow-Through Microfilters in Microfluidic Lab-on-a-Chip for Blood Typing by Microinjection Molding." ASME. J. Manuf. Sci. Eng. April 2008; 130(2): 021010. https://doi.org/10.1115/1.2896142
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