Drug-eluting stents (DES) have profoundly affected the field of interventional cardiology by dramatically reducing the problem of in-stent restenosis. However, the adverse, long-term, thrombosis raises the questions on the safety profile of DES. Femtosecond pulsed laser nanotexturing of metallic stents was performed to minimize thrombosis by improving three fundamental characteristics of DES: (1) increase the availability of drug for elution; (2) enhance the adhesion between stent and drug; and (3) minimize and, if possible, eliminate the polymer carrier. Results of laser-induced nanoprotrusion/drug interactions confirmed these benefits and indicated that femtosecond laser nanotexturing is a potential cost-effective solution for improving the performance and safety of DES while eliminating the need for postfinishing operations.
Femtosecond Laser Nanotexturing of Drug-Eluting Stents
Contributed by the Manufacturing Engineering Division of ASME for publication in the JOURNAL OF Manufacturing Science and Engineering. Manuscript received June 27, 2011; final manuscript received August 23, 2012; published online November 12, 2012. Assoc. Editor: Yong Huang.
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Nair, R., Molian, V., and Molian, P. (November 1, 2012). "Femtosecond Laser Nanotexturing of Drug-Eluting Stents." ASME. J. Manuf. Sci. Eng. December 2012; 134(6): 061008. https://doi.org/10.1115/1.4007713
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