With the growing Accreditation Council for Graduate Medical Education (ACGME) regulations, studies have increasingly reported decreased technical proficiencies by clinical trainees. One major way programs have addressed this is by adopting proficiency through simulation training. One such crucial technique is radial artery line cannulation, an invasive procedure performed by trainees across multiple medical disciplines. The objective of this project was to design a high-fidelity, pulsatile, automated radial artery line simulation model that supports ultrasound (US) guided insertion and pressure transduction that could potentially be used for technical skill development and training purposes. A radial artery line simulation model was designed using a pulsatile, arterial circuit with an alginate silicone cast molded artificial hand that supported cannulation under US guidance. The radial arterial circuit pressure was transduced to display a simulated arterial waveform and pressure. Five radial artery lines were successfully cannulated under US guidance followed by pressure transduction. The results, although qualitative, demonstrate a proof of concept. Further studies are needed to determine if the radial artery simulation model can be used as an educational tool to help train medical professionals.