Reconstructing or repairing a damaged tissue with porous scaffolds to restore the mechanical, biological, and chemical functions is one of the major tissue engineering and wound healing strategies. Recent developments in three-dimensional bioprinting techniques and improvements in the biomaterial properties have made fabrication of controlled and interconnected porous scaffold structures possible. Especially, for wound healing or soft tissue engineering, membranes/scaffolds made out of visco-elastic hydrogels, or other soft biomaterials with regular porous structures are commonly used. When the visco-elastic structures are applied onto a wound or damaged area, various forces might act upon these structures. The applied forces caused by bandage or occlusive dressings, contraction, and/or the self-weight could deform the fabricated scaffolds. As a result, the geometry and the designed porosity changes which eventually alters the desired choreographed functionality. To remedy this problem, a denser scaffold providing higher material concentration could be developed. However, denser scaffolds might have a negative impact on cell proliferation and also could block pathways for nutrient and waste transportation. In this work, a novel multifunctional visco-elastic scaffold modeling has been proposed to control the effective porosity of scaffolds. The designed scaffolds are optimized to provide spatial functionality and controlled material concentration under deformed conditions. The proposed methodology has been implemented and illustrative examples are provided in this paper. Effective porosity between the traditional and the proposed scaffold design have been compared by applying both models on the same free-form surface mimicking a wound.
Skip Nav Destination
e-mail: akm32@buffalo.edu
e-mail: bahattinkoc@sabanciuniv.edu
Article navigation
September 2012
Research Papers
Designing Controllable Porosity for Multifunctional Deformable Tissue Scaffolds
AKM Bashirul Khoda,
AKM Bashirul Khoda
Department of Industrial Engineering,
e-mail: akm32@buffalo.edu
University at Buffalo
, Buffalo, NY, 14260
Search for other works by this author on:
Bahattin Koc
Bahattin Koc
Faculty of Engineering and Natural Sciences,
e-mail: bahattinkoc@sabanciuniv.edu
Sabanci University
, Istanbul, 34956, Turkey
Search for other works by this author on:
AKM Bashirul Khoda
Department of Industrial Engineering,
University at Buffalo
, Buffalo, NY, 14260e-mail: akm32@buffalo.edu
Bahattin Koc
Faculty of Engineering and Natural Sciences,
Sabanci University
, Istanbul, 34956, Turkey
e-mail: bahattinkoc@sabanciuniv.edu
J. Med. Devices. Sep 2012, 6(3): 031003 (12 pages)
Published Online: July 30, 2012
Article history
Received:
November 28, 2011
Revised:
April 14, 2012
Online:
July 30, 2012
Published:
July 30, 2012
Citation
Khoda, A. B., and Koc, B. (July 30, 2012). "Designing Controllable Porosity for Multifunctional Deformable Tissue Scaffolds." ASME. J. Med. Devices. September 2012; 6(3): 031003. https://doi.org/10.1115/1.4007009
Download citation file:
Get Email Alerts
Development of an Anatomically Accurate Three-Dimensional Simulation Model for Pediatric Central Line Placement
J. Med. Devices (March 2024)
Related Articles
Formability of Porous Tantalum Sheet-Metal
J. Manuf. Sci. Eng (December,2011)
Effective Constitutive Equations for Porous Elastic Materials at Finite Strains and Superimposed Finite Strains
J. Appl. Mech (November,2003)
A Study of Keyhole Porosity in Selective Laser Melting: Single-Track Scanning With Micro-CT Analysis
J. Manuf. Sci. Eng (July,2019)
Related Proceedings Papers
Related Chapters
Completing the Picture
Air Engines: The History, Science, and Reality of the Perfect Engine
Multiple Smoothing and Morphological Techniques in Radiographic Image Enhancement
International Conference on Computer Engineering and Technology, 3rd (ICCET 2011)
Fractal Analysis of CT-Measured Porosity for Claypan Soils
Intelligent Engineering Systems through Artificial Neural Networks