The liver is one of the most essential organs, and transplantation is an established treatment for patients with end-stage disease who have lost their liver function. However, organ shortage is a critical problem in transplantation; thus, the development of an innovative preservation system to adopt critical grafts obtained from extended criteria donors or donation after cardiac death donors as viable organs for transplantation is necessary. We recently developed a novel rewarming machine perfusion preservation system for liver transplantation, and herein discuss this system, which allows the perfusion temperature to be controlled during the transition from hypothermic to subnormothermic conditions. This system has two functions: (1) the preservation and recovery of organ function and (2) screening the organ for viability. To achieve these functions, this system has three features: (1) temperature control of the preservation perfusate and liver graft, (2) dual-controlled perfusion of the portal vein and hepatic artery, and (3) real-time monitoring of the perfusion conditions, including the flow rate, perfusion pressure and temperature. This system was useful for liver preservation and for evaluating the graft viability and recovery of functions during machine perfusion before transplantation. This novel rewarming machine preservation system was tested in an experimental model using porcine liver grafts. We report that this system has certain advantages in liver preservation, and believe that this system will positively contribute to the expansion of the organ donor pool.
Skip Nav Destination
Article navigation
December 2013
Research-Article
Rewarming Machine Perfusion System for Liver Transplantation
Hiromichi Obara,
Hiromichi Obara
1
Department of Mechanical Engineering,
e-mail: obara@tmu.ac.jp
Tokyo Metropolitan University
,1-1 Minamiosawa, Hachioji
,Tokyo
, Japan
e-mail: obara@tmu.ac.jp
1Corresponding author.
Search for other works by this author on:
Naoto Matsuno,
Naoto Matsuno
Department of Transplantation,
Division for Advanced Medical Sciences,
Clinical Research Center,
Division for Advanced Medical Sciences,
Clinical Research Center,
National Center for Child Health and Development
,2-10-1 Okura Setagaya-ku
,Tokyo
, Japan
Search for other works by this author on:
Takanobu Shigeta,
Takanobu Shigeta
Department of Transplantation,
Clinical Research Center,
National Center for Child Health
and Development,
2-10-1 Okura Setagaya-ku,
Tokyo, Japan
Division of Hepato-Biliary-Pancreatic
and Transplant Surgery,
Clinical Research Center,
National Center for Child Health
and Development,
2-10-1 Okura Setagaya-ku,
Tokyo, Japan
Division of Hepato-Biliary-Pancreatic
and Transplant Surgery,
Kyoto University
,Yoshida-Konoe-cho,Sakyo-ku,
Kyoto
, Japan
Search for other works by this author on:
Shin Enosawa,
Shin Enosawa
Division for Advanced Medical Sciences,
Clinical Research Center,
Clinical Research Center,
National Center for Child Health and Development
,2-10-1 Okura Setagaya-ku,
Tokyo
, Japan
Search for other works by this author on:
Toshihiko Hirano,
Toshihiko Hirano
Department of Clinical Pharmacology,
Tokyo University of Pharmacy and Life Science
,1432-1 Horinouchi, Hachioji
,Tokyo
, Japan
Search for other works by this author on:
Hiroshi Mizunuma
Hiroshi Mizunuma
Department of Mechanical Engineering,
Tokyo Metropolitan University
,1-1 Minamiosawa, Hachioji
,Tokyo
, Japan
Search for other works by this author on:
Hiromichi Obara
Department of Mechanical Engineering,
e-mail: obara@tmu.ac.jp
Tokyo Metropolitan University
,1-1 Minamiosawa, Hachioji
,Tokyo
, Japan
e-mail: obara@tmu.ac.jp
Naoto Matsuno
Department of Transplantation,
Division for Advanced Medical Sciences,
Clinical Research Center,
Division for Advanced Medical Sciences,
Clinical Research Center,
National Center for Child Health and Development
,2-10-1 Okura Setagaya-ku
,Tokyo
, Japan
Takanobu Shigeta
Department of Transplantation,
Clinical Research Center,
National Center for Child Health
and Development,
2-10-1 Okura Setagaya-ku,
Tokyo, Japan
Division of Hepato-Biliary-Pancreatic
and Transplant Surgery,
Clinical Research Center,
National Center for Child Health
and Development,
2-10-1 Okura Setagaya-ku,
Tokyo, Japan
Division of Hepato-Biliary-Pancreatic
and Transplant Surgery,
Kyoto University
,Yoshida-Konoe-cho,Sakyo-ku,
Kyoto
, Japan
Shin Enosawa
Division for Advanced Medical Sciences,
Clinical Research Center,
Clinical Research Center,
National Center for Child Health and Development
,2-10-1 Okura Setagaya-ku,
Tokyo
, Japan
Toshihiko Hirano
Department of Clinical Pharmacology,
Tokyo University of Pharmacy and Life Science
,1432-1 Horinouchi, Hachioji
,Tokyo
, Japan
Hiroshi Mizunuma
Department of Mechanical Engineering,
Tokyo Metropolitan University
,1-1 Minamiosawa, Hachioji
,Tokyo
, Japan
1Corresponding author.
Manuscript received December 24, 2012; final manuscript received June 17, 2013; published online October 25, 2013. Assoc. Editor: Keefe B. Manning.
J. Med. Devices. Dec 2013, 7(4): 041011 (7 pages)
Published Online: October 25, 2013
Article history
Received:
December 24, 2012
Revision Received:
June 17, 2013
Citation
Obara, H., Matsuno, N., Shigeta, T., Enosawa, S., Hirano, T., and Mizunuma, H. (October 25, 2013). "Rewarming Machine Perfusion System for Liver Transplantation." ASME. J. Med. Devices. December 2013; 7(4): 041011. https://doi.org/10.1115/1.4025189
Download citation file:
Get Email Alerts
Related Articles
Simulation of Portal Hemodynamic Changes in a Donor After Right Hepatectomy
J Biomech Eng (April,2010)
Mathematical Modeling of the Circulation in the Liver Lobule
J Biomech Eng (November,2010)
Effect of Preservation Period on the Viscoelastic Material Properties of Soft Tissues With Implications for Liver Transplantation
J Biomech Eng (October,2010)
An Isolated Rat Liver Model for the Evaluation of Thermal Techniques to Quantify Perfusion
J Biomech Eng (August,1984)
Related Proceedings Papers
Related Chapters
Compressive Deformation of Hot-Applied Rubberized Asphalt Waterproofing
Roofing Research and Standards Development: 10th Volume
Thermodynamic Performance
Closed-Cycle Gas Turbines: Operating Experience and Future Potential
Outlook
Closed-Cycle Gas Turbines: Operating Experience and Future Potential