The purpose of this study is to demonstrate particle separation through a novel mechanism termed as “time series alternate flow” using a microdevice as it is a real challenge to separate particles with a narrow size range (i.e., or smaller), especially achieving particles separation through the hydrodynamic method without the help from additional flow or force fields. High fidelity computational fluid dynamics with particle trajectory approach was employed for simulations. Particle separation of different sizes in the range size was achieved by operating the microdevice at various actuating frequencies. The results obtained indicated that the proposed mechanism is feasible for particle separation of multiple sizes. Our novel mechanism proposed potentially represents a viable microtechnological approach for particle separation in many drug delivery applications.
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Research Papers
Separation of Particles for Drug Delivery Using a Microfluidic Device With Actuation
Guoguang Su,
Guoguang Su
Department of Mechanical Engineering,
Virginia Commonwealth University
, Richmond, VA 23284
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Ramana M. Pidaparti
Ramana M. Pidaparti
Department of Mechanical Engineering,
e-mail: rmpidaparti@vcu.edu
Virginia Commonwealth University
, Richmond, VA 23284
Search for other works by this author on:
Guoguang Su
Department of Mechanical Engineering,
Virginia Commonwealth University
, Richmond, VA 23284
Ramana M. Pidaparti
Department of Mechanical Engineering,
Virginia Commonwealth University
, Richmond, VA 23284e-mail: rmpidaparti@vcu.edu
J. Nanotechnol. Eng. Med. May 2011, 2(2): 021006 (8 pages)
Published Online: May 16, 2011
Article history
Received:
March 2, 2011
Revised:
March 15, 2011
Online:
May 16, 2011
Published:
May 16, 2011
Citation
Su, G., and Pidaparti, R. M. (May 16, 2011). "Separation of Particles for Drug Delivery Using a Microfluidic Device With Actuation." ASME. J. Nanotechnol. Eng. Med. May 2011; 2(2): 021006. https://doi.org/10.1115/1.4003930
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