... computational fluid dynamics pulsatile flow MDT is one of the major drug delivery methods that are used for treatment in different parts of our circulatory system. Among these different drug delivery methods, the magnetic targeted drug delivery system is one of the most attractive strategies due to its...

... This review discusses current progress and future challenges in the numerical modeling of targeted drug delivery using functionalized nanocarriers (NC). Antibody coated nanocarriers of various size and shapes, also called functionalized nanocarriers, are designed to be injected in the vasculature, whereby they undergo translational and rotational motion governed by hydrodynamic interaction with blood particulates as well as adhesive interactions mediated by the surface antibody binding to target antigens/receptors on cell surfaces. We review current multiscale modeling approaches rooted in computational fluid dynamics and nonequilibrium statistical mechanics to accurately resolve fluid, thermal, as well as adhesive interactions governing nanocarrier motion and their binding to endothelial cells lining the vasculature. We also outline current challenges and unresolved issues surrounding the modeling methods. Experimental approaches in pharmacology and bioengineering are discussed briefly from the perspective of model validation....

... achieving particles separation through the hydrodynamic method without the help from additional flow or force fields. High fidelity computational fluid dynamics with particle trajectory approach was employed for simulations. Particle separation of different sizes in the range 2 – 10 μ m size was achieved...

... hemodynamic flow computational fluid dynamics An Eulerian-Lagrangian approach is adopted to solve the particle-laden flow through the blood vessel. The coupled mass and momentum equations for the liquid phase are solved using a numerical code, which is based on Solution Algorithm (SOLA...

... applications of nanomechanical forces with the promise of inducing regeneration or changing the trajectory of degenerative cellular processes. biomechanics bioMEMS cellular biophysics computational fluid dynamics diseases microfluidics patient monitoring 29 01 2010 12 02 2010 05...