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Keywords: extracellular matrix
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Journal Articles

Three-Dimensional Culture of Cells and Matrix Biomolecules for Engineered Tissue Development and Biokinetics Model Validation

Shelley S. Mason, Sean S. Kohles, Randy D. Zelick, Shelley R. Winn, Asit K. Saha
Journal: Journal of Nanotechnology in Engineering and Medicine
Article Type: Design Innovation Paper
J. Nanotechnol. Eng. Med. May 2011, 2(2): 025001.
DOI: https://doi.org/10.1115/1.4003878
Published Online: May 19, 2011
... in tissue culture. In particular, a novel chemomechanical bioreactor has recently been designed for the study of bone and cartilage tissue development, with particular focus on extracellular matrix formation. The bioreactor is equally significant as a tool for validation of mathematical models that explore...
View Article titled, Three-Dimensional Culture of Cells and Matrix Biomolecules for Engineered Tissue Development and Biokinetics Model Validation
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Topics: Biological tissues, Biomaterials, Bioreactors, Cartilage, Chondrocytes
Journal Articles

Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis

Asit K. Saha, Sean S. Kohles
Journal: Journal of Nanotechnology in Engineering and Medicine
Article Type: Research Papers
J. Nanotechnol. Eng. Med. November 2010, 1(4): 041001.
DOI: https://doi.org/10.1115/1.4002461
Published Online: October 21, 2010
... a Mechanically Functional Extracellular Matrix ,” J. Orthop. Res. 0736-0266 , 10 , pp. 745 – 758 . 10.1002/jor.1100100602 Freed , L. E. , Marquis , J. C. , Nohria , A. , Emmanual , J. , Mikos , A. G. , and Langer , R. , 1993 , “ Neocartilage Formation In Vitro and In Vivo...
View Article titled, Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis
Click here to open pdf in another window PDF for Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis
Topics: Biological tissues, Biomechanics, Cartilage, Chondrocytes, Steady state, Stress, Dynamics (Mechanics), Nanoscale phenomena, Modeling