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Proceedings Papers

Experimental Visualization of Lagrangian Coherent Structures in Aperiodic Free Surface Flow

Antonis Chrisohoides, Fotis Sotiropoulos
Proc. ASME. IMECE2001, Fluids Engineering, 69-77, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/FED-24933
https://doi.org/10.1115/IMECE2001/FED-24933
View Paper titled, Experimental Visualization of Lagrangian Coherent Structures in Aperiodic Free Surface Flow
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Topics: Flow (Dynamics), Visualization, Corners (Structural elements), Eddies (Fluid dynamics), Open channels (Hydraulics), Photography, Turbulence
Proceedings Papers

A Non-Intrusive Experimental Technique for Constructing Poincaré Maps in 3D Chaotically Advected Flows

Fotis Sotiropoulos, Igor Mezić, Donald R. Webster
Proc. ASME. IMECE2001, Fluids Engineering, 61-68, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/FED-24932
https://doi.org/10.1115/IMECE2001/FED-24932
View Paper titled, A Non-Intrusive Experimental Technique for Constructing Poincaré Maps in 3D Chaotically Advected Flows
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Topics: Flow (Dynamics), Poincaré maps, Lasers, Bubbles, Chain, Computer simulation, Cylinders, Dynamics (Mechanics), Ergodic theory, Fluorescence
Proceedings Papers

The Lagrangian Dynamics of Steady Vortex Breakdown Bubbles

Fotis Sotiropoulos, Tahirih C. Lackey
Proc. ASME. IMECE2001, Fluids Engineering, 9-16, November 11–16, 2001
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2001/FED-24925
https://doi.org/10.1115/IMECE2001/FED-24925
View Paper titled, The Lagrangian Dynamics of Steady Vortex Breakdown Bubbles
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Topics: Bubbles, Dynamics (Mechanics), Vortices, Bifurcation, Cylinders, Dynamic systems, Flow (Dynamics), Particulate matter, Phase space
Journal Articles

Flow–Structure Interaction Simulations of the Aortic Heart Valve at Physiologic Conditions: The Role of Tissue Constitutive Model

Anvar Gilmanov, Henryk Stolarski, Fotis Sotiropoulos
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2018, 140(4): 041003.
Paper No: BIO-16-1530
https://doi.org/10.1115/1.4038885
Published Online: January 23, 2018
View Article titled, Flow–Structure Interaction Simulations of the Aortic Heart Valve at Physiologic Conditions: The Role of Tissue Constitutive Model
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Topics: Blood flow, Constitutive equations, Flow (Dynamics), Fluid structure interaction, Simulation, Valves, Physiology, Biological tissues, Aorta, Fluids
Proceedings Papers

Vortex Dynamics in Sidewall Aneurysms: Hemodynamic Transition During Growth and Clinical Implications

Trung Bao Le, Fotis Sotiropoulos
Proc. ASME. DMD2017, 2017 Design of Medical Devices Conference, V001T09A003, April 10–13, 2017
Publisher: American Society of Mechanical Engineers
Paper No: DMD2017-3406
https://doi.org/10.1115/DMD2017-3406
View Paper titled, Vortex Dynamics in Sidewall Aneurysms: Hemodynamic Transition During Growth and Clinical Implications
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Topics: Aneurysms, Dynamics (Mechanics), Hemodynamics, Vortices, Computer simulation, Domes (Structural elements), Flow (Dynamics), Pressure, Rupture, Shapes
Journal Articles

A Novel Bioreactor for Mechanobiological Studies of Engineered Heart Valve Tissue Formation Under Pulmonary Arterial Physiological Flow Conditions

Sharan Ramaswamy, Steven M. Boronyak, Trung Le, Andrew Holmes, Fotis Sotiropoulos, Michael S. Sacks
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2014, 136(12): 121009.
Paper No: BIO-13-1301
https://doi.org/10.1115/1.4028815
Published Online: December 1, 2014
View Article titled, A Novel Bioreactor for Mechanobiological Studies of Engineered Heart Valve Tissue Formation Under Pulmonary Arterial Physiological Flow Conditions
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Topics: Biological tissues, Bioreactors, Flow (Dynamics), Fluids, Shear stress, Valves, Physiology, Design
Proceedings Papers

Simulations of the Hinge Flow Fields of a Bileaflet Mechanical Heart Valve Under Physiologic Pulsatile Aortic Conditions

Hélène A. Simon, Liang Ge, Iman Borazjani, Fotis Sotiropoulos, Ajit P. Yoganathan
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 1093-1094, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192939
https://doi.org/10.1115/SBC2008-192939
View Paper titled, Simulations of the Hinge Flow Fields of a Bileaflet Mechanical Heart Valve Under Physiologic Pulsatile Aortic Conditions
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Topics: Engineering simulation, Flow (Dynamics), Heart valve prostheses, Hinges, Physiology, Simulation, Valves, Design, Blood, Hemodynamics
Proceedings Papers

Modeling the Role of Oscillatory Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell Derived Heart Valve Tissue Engineering

João S. Soares, Trung L. Le, Fotis Sotiropoulos, Michael S. Sacks
Proc. ASME. FMD2013, ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, V001T07A003, September 11–13, 2013
Publisher: American Society of Mechanical Engineers
Paper No: FMD2013-16165
https://doi.org/10.1115/FMD2013-16165
View Paper titled, Modeling the Role of Oscillatory Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell Derived Heart Valve Tissue Engineering
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Topics: Biological tissues, Flow (Dynamics), Modeling, Stem cells, Tissue engineering, Valves, Bioreactors, Computational fluid dynamics, Bioengineering, Boundary-value problems
Proceedings Papers

Simulation of the Role of Oscillatory Shear Stress on Mesenchymal Stem Cell Proliferation and Extracellular Matrix Production in Engineered Heart Valve Tissue Formation

João S. Soares, Trung B. Le, Fotis Sotiropoulos, Michael S. Sacks
Proc. ASME. SBC2013, Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, V01AT15A001, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14180
https://doi.org/10.1115/SBC2013-14180
View Paper titled, Simulation of the Role of Oscillatory Shear Stress on Mesenchymal Stem Cell Proliferation and Extracellular Matrix Production in Engineered Heart Valve Tissue Formation
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Topics: Biological tissues, Shear stress, Simulation, Stem cells, Valves, Biodegradation, Bone, Hemodynamics, Maintenance, Pediatrics
Journal Articles

Modeling the Role of Oscillator Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell–Derived Heart Valve Tissue Engineering

João S. Soares, Trung B. Le, Fotis Sotiropoulos, Michael S. Sacks
Journal: Journal of Medical Devices
Publisher: ASME
Article Type: Frontiers Abstracts
J. Med. Devices. December 2013, 7(4): 040927.
Paper No: MED-13-1248
https://doi.org/10.1115/1.4025984
Published Online: December 5, 2013
View Article titled, Modeling the Role of Oscillator Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell–Derived Heart Valve Tissue Engineering
Open the PDF for Modeling the Role of Oscillator Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell–Derived Heart Valve Tissue Engineering in another window
Topics: Biological tissues, Flow (Dynamics), Modeling, Stem cells, Tissue engineering, Valves
Proceedings Papers

Phase-Locked PIV Measurement in the Wake of Model Wind Turbines Under Various Inflow Conditions

David J. Green, Leonardo P. Chamorro, Roger E. Arndt, Fotis Sotiropoulos, Jian Sheng
Proc. ASME. FEDSM2012, Volume 1: Symposia, Parts A and B, 1507-1514, July 8–12, 2012
Publisher: American Society of Mechanical Engineers
Paper No: FEDSM2012-72331
https://doi.org/10.1115/FEDSM2012-72331
View Paper titled, Phase-Locked PIV Measurement in the Wake of Model Wind Turbines Under Various Inflow Conditions
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Topics: Inflow, Wakes, Wind turbines, Turbines, Flow (Dynamics), Turbulence, Rotors, Wake turbulence, Boundary layer turbulence, Boundary layers
Proceedings Papers

Device Specific Aortic Outflow Cannula Jets Studied Using 2D PIV and High-Performance 3D CFD Simulation

Prahlad G. Menon, Nikola Teslovich, Chia-Yuan Chen, Fotis Sotiropoulos, Akif Undar, Kerem Pekkan
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 67-68, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80454
https://doi.org/10.1115/SBC2012-80454
View Paper titled, Device Specific Aortic Outflow Cannula Jets Studied Using 2D PIV and High-Performance 3D CFD Simulation
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Topics: Computational fluid dynamics, Jets, Outflow, Simulation, Blood, Flow (Dynamics), Blood flow, Surgery, Wakes, Circuits
Proceedings Papers

Development of an Anatomically Realistic Left Ventricle Physical Model and Multi-Modality Experimental Platform for Validation of Patient-Specific Computational Simulations

Brandon Chaffins, Trung Le, Arvind Santhanakrishnan, Lucia Mirabella, Fotis Sotiropoulos, Ajit Yoganathan
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 567-568, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80613
https://doi.org/10.1115/SBC2012-80613
View Paper titled, Development of an Anatomically Realistic Left Ventricle Physical Model and Multi-Modality Experimental Platform for Validation of Patient-Specific Computational Simulations
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Topics: Engineering simulation, Simulation, Computational fluid dynamics, Diseases, Flow (Dynamics), Bioengineering, Biomedicine, Deformation, Dynamics (Mechanics), Food and Drug Administration
Proceedings Papers

CFD Challenge: Computational Hemodynamics Analysis of Patient-Specific Internal Carotid Artery Aneursym Using an In-House Finite Difference Cardiovascular Flow Solver

Prahlad G. Menon, Fotis Sotiropoulos, Kerem Pekkan
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 131-132, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80457
https://doi.org/10.1115/SBC2012-80457
View Paper titled, CFD Challenge: Computational Hemodynamics Analysis of Patient-Specific Internal Carotid Artery Aneursym Using an In-House Finite Difference Cardiovascular Flow Solver
Open the PDF for CFD Challenge: Computational Hemodynamics Analysis of Patient-Specific Internal Carotid Artery Aneursym Using an In-House Finite Difference Cardiovascular Flow Solver in another window
Topics: Cardiovascular system, Carotid arteries, Computational fluid dynamics, Flow (Dynamics), Hemodynamics, Internal flow, Aneurysms, Aortic arch, Engineering simulation, Fluid mechanics
Journal Articles

High Resolution Simulation of Tri-Leaflet Aortic Heart Valve in an Idealized Aorta

Trung Bao Le, Anvar Gilmanov, Fotis Sotiropoulos
Journal: Journal of Medical Devices
Publisher: ASME
Article Type: Technical Briefs
J. Med. Devices. September 2013, 7(3): 030930.
Paper No: MED-13-1088
https://doi.org/10.1115/1.4024520
Published Online: July 3, 2013
View Article titled, High Resolution Simulation of Tri-Leaflet Aortic Heart Valve in an Idealized Aorta
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Topics: Aorta, Resolution (Optics), Simulation, Valves, Flow (Dynamics)
Journal Articles

A Process for Design, Verification, Validation, and Manufacture of Medical Devices Using Immersive VR Environments

Daniel F. Keefe, Fotis Sotiropoulos, Victoria Interrante, H. Birali Runesha, Dane Coffey, Molly Staker, Chi-Lun Lin, Yi Sun, Iman Borazjani, Trung Le, Nancy Rowe, Arthur Erdman
Journal: Journal of Medical Devices
Publisher: ASME
Article Type: Design Innovations
J. Med. Devices. December 2010, 4(4): 045002.
https://doi.org/10.1115/1.4002561
Published Online: November 3, 2010
View Article titled, A Process for Design, Verification, Validation, and Manufacture of Medical Devices Using Immersive VR Environments
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Topics: Computational fluid dynamics, Design, Medical devices, Simulation, Visualization, Valves, Virtual reality, Engineering simulation, Computers
Journal Articles

Pulsatile Flow Effects on the Hemodynamics of Intracranial Aneurysms

Trung B. Le, Iman Borazjani, Fotis Sotiropoulos
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. November 2010, 132(11): 111009.
https://doi.org/10.1115/1.4002702
Published Online: October 27, 2010
View Article titled, Pulsatile Flow Effects on the Hemodynamics of Intracranial Aneurysms
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Topics: Aneurysms, Domes (Structural elements), Flow (Dynamics), Hemodynamics, Vortices, Shear stress, Cavities, Inflow, Pulsatile flow, Reynolds number
Journal Articles

The Effect of Implantation Orientation of a Bileaflet Mechanical Heart Valve on Kinematics and Hemodynamics in an Anatomic Aorta

Iman Borazjani, Fotis Sotiropoulos
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. November 2010, 132(11): 111005.
https://doi.org/10.1115/1.4002491
Published Online: October 15, 2010
View Article titled, The Effect of Implantation Orientation of a Bileaflet Mechanical Heart Valve on Kinematics and Hemodynamics in an Anatomic Aorta
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Topics: Aorta, Flow (Dynamics), Heart valve prostheses, Hemodynamics, Kinematics, Shear stress, Simulation, Valves, Magnetic resonance imaging, Fluid structure interaction
Journal Articles

Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification?

Liang Ge, Fotis Sotiropoulos
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. January 2010, 132(1): 014505.
https://doi.org/10.1115/1.4000162
Published Online: December 9, 2009
View Article titled, Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification?
Open the PDF for Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification? in another window
Topics: Blood flow, Flow (Dynamics), Hemodynamics, Shear stress, Valves, Endothelial cells
Proceedings Papers

Fluid-Structure Interaction in Bi-Leaflet Mechanical Heart Valves

Iman Borazjani, Liang Ge, Fotis Sotiropoulos, Lakshmi Prasad Dasi, Ajit Yogonathan
Proc. ASME. BIOMED2007, ASME 2007 2nd Frontiers in Biomedical Devices, 17-18, June 7–8, 2007
Publisher: American Society of Mechanical Engineers
Paper No: BioMed2007-38074
https://doi.org/10.1115/BioMed2007-38074
View Paper titled, Fluid-Structure Interaction in Bi-Leaflet Mechanical Heart Valves
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Topics: Fluid structure interaction, Heart valve prostheses, Aorta, Cardiac cycle, Computer simulation, Flow (Dynamics), Fluid dynamics, Geometry, Kinematics, Simulation