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Journal Articles

Experimental Hemodynamics Within the Penn State Fontan Circulatory Assist Device

Sailahari V. Ponnaluri, Emma J. Christensen, Bryan C. Good, Cody J. Kubicki, Steven Deutsch, Joshua P. Cysyk, William J. Weiss, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2022, 144(7): 071004.
Paper No: BIO-21-1273
https://doi.org/10.1115/1.4053210
Published Online: February 15, 2022
View Article titled, Experimental Hemodynamics Within the Penn State Fontan Circulatory Assist Device
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Topics: Flow (Dynamics), Pumps, Hemodynamics, Rotors, Physiology
Journal Articles

Characterizing the HeartMate II Left Ventricular Assist Device Outflow Using Particle Image Velocimetry

Grant W. Rowlands, Bryan C. Good, Steven Deutsch, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2018, 140(7): 071008.
Paper No: BIO-17-1326
https://doi.org/10.1115/1.4039822
Published Online: April 30, 2018
View Article titled, Characterizing the HeartMate II Left Ventricular Assist Device Outflow Using Particle Image Velocimetry
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Topics: Flow (Dynamics), Particulate matter, Stress, Cardiac cycle, Ventricular assist devices, Physiology, Pumps, Shear stress
Journal Articles

In Vitro Quantification of Time Dependent Thrombus Size Using Magnetic Resonance Imaging and Computational Simulations of Thrombus Surface Shear Stresses

Joshua O. Taylor, Kory P. Witmer, Thomas Neuberger, Brent A. Craven, Richard S. Meyer, Steven Deutsch, Keefe B. Manning
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2014, 136(7): 071012.
Paper No: BIO-13-1526
https://doi.org/10.1115/1.4027613
Published Online: May 23, 2014
View Article titled, In Vitro Quantification of Time Dependent Thrombus Size Using Magnetic Resonance Imaging and Computational Simulations of Thrombus Surface Shear Stresses
Open the PDF for In Vitro Quantification of Time Dependent Thrombus Size Using Magnetic Resonance Imaging and Computational Simulations of Thrombus Surface Shear Stresses in another window
Topics: Thrombosis, Magnetic resonance imaging, Blood flow, Computational fluid dynamics, Flow (Dynamics), Simulation
Proceedings Papers

Impact of Outlet Valve Orientation on Fluid Dynamics of the 12 cc Penn State Pediatric Ventricular Assist Device

Isabella E. Valenti, Breigh N. Roszelle, Michael V. Perone, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 427-428, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192744
https://doi.org/10.1115/SBC2008-192744
View Paper titled, Impact of Outlet Valve Orientation on Fluid Dynamics of the 12 cc Penn State Pediatric Ventricular Assist Device
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Topics: Fluid dynamics, Pediatrics, Valves, Ventricular assist devices, Blood flow, Bridges (Structures), Cardiovascular system, Diseases, Interior walls, Thrombosis
Proceedings Papers

A Comprehensive Flow Study of the 12 cc Penn State Pulsatile Pediatric Ventricular Assist Device

Breigh N. Roszelle, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 1037-1038, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192743
https://doi.org/10.1115/SBC2008-192743
View Paper titled, A Comprehensive Flow Study of the 12 cc Penn State Pulsatile Pediatric Ventricular Assist Device
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Topics: Flow (Dynamics), Pediatrics, Ventricular assist devices, Blood, Biomedicine, Design, Flow visualization, Fluid dynamics, Gates (Closures), Lung
Proceedings Papers

Numerical Study of Blood Flow at the End-to-Side Anastomosis of a Left Ventricular Assist Device for Adult Patients

Ning Yang, Steven Deutsch, Eric G. Paterson, Keefe B. Manning
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 1039-1040, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192745
https://doi.org/10.1115/SBC2008-192745
View Paper titled, Numerical Study of Blood Flow at the End-to-Side Anastomosis of a Left Ventricular Assist Device for Adult Patients
Open the PDF for Numerical Study of Blood Flow at the End-to-Side Anastomosis of a Left Ventricular Assist Device for Adult Patients in another window
Topics: Blood flow, Ventricular assist devices, Flow (Dynamics), Aorta, Outflow, Turbulence, Computational fluid dynamics, Vessels, Aortic arch, Bridges (Structures)
Proceedings Papers

Using Animal Models to Study Pediatric Cardiovascular Devices: The Impact on Fluid Dynamics

Tobias C. Long, Michael V. Perone, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 977-978, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192747
https://doi.org/10.1115/SBC2008-192747
View Paper titled, Using Animal Models to Study Pediatric Cardiovascular Devices: The Impact on Fluid Dynamics
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Topics: Cardiovascular devices, Fluid dynamics, Pediatrics, Blood, Bridges (Structures), Heart failure, Particulate matter, Ventricular assist devices
Proceedings Papers

Correlating Leaflet Design and Closing Dynamics With Turbulent Flows Near Bileaflet Mechanical Heart Valves

Luke H. Herbertson, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 1091-1092, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192508
https://doi.org/10.1115/SBC2008-192508
View Paper titled, Correlating Leaflet Design and Closing Dynamics With Turbulent Flows Near Bileaflet Mechanical Heart Valves
Open the PDF for Correlating Leaflet Design and Closing Dynamics With Turbulent Flows Near Bileaflet Mechanical Heart Valves in another window
Topics: Design, Dynamics (Mechanics), Heart valve prostheses, Turbulence, Valves, Fluid mechanics, Patient treatment, Thrombosis
Proceedings Papers

A Fluid Dynamics Study Focusing on Wall Shear Rates Within the Penn State 12 cc Pulsatile Pediatric Ventricular Assist Device: A Comparison of Mechanical Heart Valve Types

Benjamin T. Cooper, Breigh N. Roszelle, Tobias C. Long, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 679-680, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-175441
https://doi.org/10.1115/SBC2007-175441
View Paper titled, A Fluid Dynamics Study Focusing on Wall Shear Rates Within the Penn State 12 cc Pulsatile Pediatric Ventricular Assist Device: A Comparison of Mechanical Heart Valve Types
Open the PDF for A Fluid Dynamics Study Focusing on Wall Shear Rates Within the Penn State 12 cc Pulsatile Pediatric Ventricular Assist Device: A Comparison of Mechanical Heart Valve Types in another window
Topics: Fluid dynamics, Heart valve prostheses, Pediatrics, Shear rate, Ventricular assist devices, Valves, Flow (Dynamics), Disks, Jets, Particulate matter
Proceedings Papers

Fluid Mechanical Analysis at Closure of the On-X Mechanical Heart Valve

Christopher M. Haggerty, Luke H. Herbertson, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 687-688, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-175949
https://doi.org/10.1115/SBC2007-175949
View Paper titled, Fluid Mechanical Analysis at Closure of the On-X Mechanical Heart Valve
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Topics: Fluid mechanics, Heart valve prostheses, Valves, Flow (Dynamics), Biomedicine, Carbon, Dynamics (Mechanics), Geometry, Hinges, Laser Doppler anemometry
Proceedings Papers

Development of a Wavelet Analytical Tool for Isolating and Evaluating Cavitation-Induced Hemolysis Generated During Mechanical Heart Valve Closure

Luke H. Herbertson, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 139-140, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-175538
https://doi.org/10.1115/SBC2007-175538
View Paper titled, Development of a Wavelet Analytical Tool for Isolating and Evaluating Cavitation-Induced Hemolysis Generated During Mechanical Heart Valve Closure
Open the PDF for Development of a Wavelet Analytical Tool for Isolating and Evaluating Cavitation-Induced Hemolysis Generated During Mechanical Heart Valve Closure in another window
Topics: Cavitation, Heart valve prostheses, Wavelets, Acoustics, Valves, Blood, Fluctuations (Physics), Pressure, Signals
Proceedings Papers

The Fluid Dynamic Effects Within the 12cc Penn State Pediatric Ventricular Assist Device When Altering the End Diastolic Delay

Benjamin T. Cooper, Breigh N. Roszelle, Tobias C. Long, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2009, ASME 2009 Summer Bioengineering Conference, Parts A and B, 59-60, June 17–21, 2009
Publisher: American Society of Mechanical Engineers
Paper No: SBC2009-204303
https://doi.org/10.1115/SBC2009-204303
View Paper titled, The Fluid Dynamic Effects Within the 12cc Penn State Pediatric Ventricular Assist Device When Altering the End Diastolic Delay
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Topics: Delays, Fluids, Pediatrics, Ventricular assist devices, Bridges (Structures), Diseases, Membranes
Proceedings Papers

A Correlative Study of Fluid Mechanics and Evidence of Thrombus Formation Within the Penn State 50 CC Left Ventricular Assist Device

Stephen R. Topper, Michael A. Navitsky, Christopher A. Siedlecki, Steven Deutsch, Gerson Rosenberg, Keefe B. Manning
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 783-784, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80576
https://doi.org/10.1115/SBC2012-80576
View Paper titled, A Correlative Study of Fluid Mechanics and Evidence of Thrombus Formation Within the Penn State 50 CC Left Ventricular Assist Device
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Topics: Fluid mechanics, Thrombosis, Ventricular assist devices, Bridges (Structures), Diseases, Cardiovascular system, Design, Patient treatment, Pumps
Proceedings Papers

A Comparison of Thrombus Susceptibility for Two Pulsatile 50 CC Left Ventricular Assist Pumps

Michael A. Navitsky, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 69-70, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80570
https://doi.org/10.1115/SBC2012-80570
View Paper titled, A Comparison of Thrombus Susceptibility for Two Pulsatile 50 CC Left Ventricular Assist Pumps
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Topics: Bridges (Structures), Diseases, Heart failure, Pumps, Thrombosis, Ventricular assist devices
Proceedings Papers

Experimental and Computational Studies of a Formed Thrombus Within a Backward-Facing Step Geometry

Joshua O. Taylor, Kory P. Witmer, Thomas Neuberger, Brent A. Craven, Richard S. Meyer, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 1315-1316, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80571
https://doi.org/10.1115/SBC2012-80571
View Paper titled, Experimental and Computational Studies of a Formed Thrombus Within a Backward-Facing Step Geometry
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Topics: Geometry, Thrombosis, Diseases, Atherosclerosis, Blood, Cardiovascular devices, Cardiovascular system, Failure, Fluid mechanics, Heart failure
Proceedings Papers

Multi-Laboratory Uncertainty Analysis of PIV-Measured Flow Quantities Relevant to Blood Damage in the FDA Nozzle Model

Prasanna Hariharan, Matthew Giarra, Varun Reddy, Steven W. Day, Keefe B. Manning, Steven Deutsch, Matthew R. Myers, Sandy F. C. Stewart, Greg W. Burgreen, Eric G. Paterson, Richard A. Malinauskas
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 301-302, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53644
https://doi.org/10.1115/SBC2011-53644
View Paper titled, Multi-Laboratory Uncertainty Analysis of PIV-Measured Flow Quantities Relevant to Blood Damage in the FDA Nozzle Model
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Topics: Blood, Damage, Flow (Dynamics), Food and Drug Administration, Frequency-domain analysis, Nozzles, Uncertainty analysis, Computational fluid dynamics, Shear (Mechanics), Uncertainty
Proceedings Papers

A Particle Image Velocimetry Study of the Penn State 50cc Left Ventricular Assist Device: The Impact of Varying Heart Rate

Michael A. Navitsky, Jason C. Nanna, Stephen R. Topper, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 295-296, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53207
https://doi.org/10.1115/SBC2011-53207
View Paper titled, A Particle Image Velocimetry Study of the Penn State 50cc Left Ventricular Assist Device: The Impact of Varying Heart Rate
Open the PDF for A Particle Image Velocimetry Study of the Penn State 50cc Left Ventricular Assist Device: The Impact of Varying Heart Rate in another window
Topics: Particulate matter, Ventricular assist devices, Heart failure, Bridges (Structures), Cavities, Patient treatment, Thrombosis
Proceedings Papers

Experimental Wall Shear Estimation as a Means of Predicting Thrombus Formation Within a 50cc Penn State Blood Pump

Jason C. Nanna, Stephen R. Topper, Ning Yang, Breigh N. Roszelle, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 127-128, June 16–19, 2010
Publisher: American Society of Mechanical Engineers
Paper No: SBC2010-19552
https://doi.org/10.1115/SBC2010-19552
View Paper titled, Experimental Wall Shear Estimation as a Means of Predicting Thrombus Formation Within a 50cc Penn State Blood Pump
Open the PDF for Experimental Wall Shear Estimation as a Means of Predicting Thrombus Formation Within a 50cc Penn State Blood Pump in another window
Topics: Blood, Pumps, Shear (Mechanics), Thrombosis, Flow (Dynamics), Fluid mechanics, Patient treatment, Shear rate, Ventricular assist devices
Proceedings Papers

The Challenges of Developing a Pediatric Ventricular Assist Device From a Fluid Dynamics Perspective

Breigh N. Roszelle, Benjamin T. Cooper, Ning Yang, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 241-242, June 16–19, 2010
Publisher: American Society of Mechanical Engineers
Paper No: SBC2010-19549
https://doi.org/10.1115/SBC2010-19549
View Paper titled, The Challenges of Developing a Pediatric Ventricular Assist Device From a Fluid Dynamics Perspective
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Topics: Fluid dynamics, Pediatrics, Ventricular assist devices, Medical devices
Proceedings Papers

In Vitro Viscoelastic Flow Measurements of a Pediatric End-to-Side Anastomosis to the 12cc Penn State Ventricular Assist Device

Michael V. Perone, Ning Yang, Breigh N. Roszelle, Steven Deutsch, Keefe B. Manning
Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 625-626, June 16–19, 2010
Publisher: American Society of Mechanical Engineers
Paper No: SBC2010-19542
https://doi.org/10.1115/SBC2010-19542
View Paper titled, In Vitro Viscoelastic Flow Measurements of a Pediatric End-to-Side Anastomosis to the 12cc Penn State Ventricular Assist Device
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Topics: Accounting, Cardiovascular system, Flow measurement, Pediatrics, Ventricular assist devices