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Proceedings Papers

Separation of CTCs From Blood Cells Using Curved Contraction-Expansion Microchannel Equipped With DEP Force

Md Tanbir Sarowar, Md Sadiqul Islam, Xiaolin Chen
Proc. ASME. IMECE2023, Volume 12: Micro- and Nano-Systems Engineering and Packaging, V012T13A026, October 29–November 2, 2023
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2023-112803
https://doi.org/10.1115/IMECE2023-112803
View Paper titled, Separation of CTCs From Blood Cells Using Curved Contraction-Expansion Microchannel Equipped With DEP Force
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Topics: Blood, Microchannels, Microfluidics, Separation (Technology), Tumors
Proceedings Papers

DESIGN OF A HYBRID-INERTIAL DEVICE FOR THE SEPARATION OF CIRCULATING TUMOR CELLS

Mohammed Raihan Uddin, Xiaolin Chen
Proc. ASME. DMD2023, 2023 Design of Medical Devices Conference, V001T02A002, April 17–19, 2023
Publisher: American Society of Mechanical Engineers
Paper No: DMD2023-1844
https://doi.org/10.1115/DMD2023-1844
View Paper titled, DESIGN OF A HYBRID-INERTIAL DEVICE FOR THE SEPARATION OF CIRCULATING TUMOR CELLS
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Proceedings Papers

Circulating Tumor Cell Separation in a Zigzag Channel Using Dielectrophoresis Based Inertial Microfluidics

Md Sadiqul Islam, Mohammed Raihan Uddin, Xiaolin Chen
Proc. ASME. IMECE2022, Volume 8: Fluids Engineering; Heat Transfer and Thermal Engineering, V008T10A014, October 30–November 3, 2022
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2022-95384
https://doi.org/10.1115/IMECE2022-95384
View Paper titled, Circulating Tumor Cell Separation in a Zigzag Channel Using Dielectrophoresis Based Inertial Microfluidics
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Topics: Dielectrophoresis, Microfluidics, Separation (Technology), Tumors
Proceedings Papers

Analysis of EBR-II Loss-of-Flow Transients With 3D Model of CATHARE Code

Xiaolin Chen, Simon Li, Songbai Cheng
Proc. ASME. ICONE29, Volume 4: SMRs, Advanced Reactors, and Fusion, V004T04A025, August 8–12, 2022
Publisher: American Society of Mechanical Engineers
Paper No: ICONE29-92109
https://doi.org/10.1115/ICONE29-92109
View Paper titled, Analysis of EBR-II Loss-of-Flow Transients With 3D Model of CATHARE Code
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Topics: Accidents, Flow (Dynamics), Sodium fast reactors, Three-dimensional models, Transients (Dynamics)
Journal Articles

Automated Procedure for Constructing ASME External Pressure Charts

Maan Jawad, Xiaolin Chen, Don Griffin
Journal: Journal of Pressure Vessel Technology
Publisher: ASME
Article Type: Technical Briefs
J. Pressure Vessel Technol. April 2022, 144(2): 024501.
Paper No: PVT-20-1271
https://doi.org/10.1115/1.4051851
Published Online: August 18, 2021
View Article titled, Automated Procedure for Constructing ASME External Pressure Charts
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Topics: External pressure, Stress-strain curves, Stress, Boilers, Construction
Proceedings Papers

Separation of Non-Viable Chinese Hamster Ovary (CHO) Cells Using Dielectrophoresis in a Deterministic Lateral Displacement Ratchet

Mohammed Khan, Xiaolin Chen, Jie Xu
Proc. ASME. IMECE2020, Volume 13: Micro- and Nano-Systems Engineering and Packaging, V013T13A008, November 16–19, 2020
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2020-23520
https://doi.org/10.1115/IMECE2020-23520
View Paper titled, Separation of Non-Viable Chinese Hamster Ovary (CHO) Cells Using Dielectrophoresis in a Deterministic Lateral Displacement Ratchet
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Topics: Dielectrophoresis, Displacement, Separation (Technology)
Proceedings Papers

On the Design of a DLD-DEP Device for Separation of Circulating Tumor Cells in Blood

Mehdi Rahmati, Xiaolin Chen
Proc. ASME. IMECE2020, Volume 13: Micro- and Nano-Systems Engineering and Packaging, V013T13A014, November 16–19, 2020
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2020-23505
https://doi.org/10.1115/IMECE2020-23505
View Paper titled, On the Design of a DLD-DEP Device for Separation of Circulating Tumor Cells in Blood
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Topics: Blood, Design, Separation (Technology), Tumors, Cancer, Dielectrophoresis, Flow (Dynamics), Particulate matter, Computer simulation, Displacement
Proceedings Papers

Towards Deep Learning Approaches for Quantitative Analysis of High-Throughput DLD

Eric A. Gioe, Xiaolin Chen, Jong-Hoon Kim
Proc. ASME. IMECE2020, Volume 13: Micro- and Nano-Systems Engineering and Packaging, V013T13A015, November 16–19, 2020
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2020-24269
https://doi.org/10.1115/IMECE2020-24269
View Paper titled, Towards Deep Learning Approaches for Quantitative Analysis of High-Throughput DLD
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Topics: Biological cells, Displacement, Errors, Flow (Dynamics), Machine learning, Microfluidics, Particulate matter, Separation (Technology), Tumors
Journal Articles

Compound Droplet Modeling for Circulating Tumor Cell Microfiltration With Adaptive Meshing Refinement

Mohammad Abul Hashem, Arian Aghilinejad, Xiaolin Chen, Hua Tan
Journal: Journal of Fluids Engineering
Publisher: ASME
Article Type: Research-Article
J. Fluids Eng. November 2020, 142(11): 111403.
Paper No: FE-20-1103
https://doi.org/10.1115/1.4048134
Published Online: September 4, 2020
View Article titled, Compound Droplet Modeling for Circulating Tumor Cell Microfiltration With Adaptive Meshing Refinement
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Topics: Deformation, Drops, Filtration, Flow (Dynamics), Microfiltration, Pressure, Tumors, Viscosity, Surface tension, Modeling
Proceedings Papers

Enhancing the Cell Viability in High Throughput Deterministic Lateral Displacement Separation of Circulating Tumor Cells

Arian Aghilinejad, Christopher Landry, George Cha, Xiaolin Chen
Proc. ASME. IMECE2019, Volume 7: Fluids Engineering, V007T08A048, November 11–14, 2019
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2019-10209
https://doi.org/10.1115/IMECE2019-10209
View Paper titled, Enhancing the Cell Viability in High Throughput Deterministic Lateral Displacement Separation of Circulating Tumor Cells
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Topics: Displacement, Reynolds number, Separation (Technology), Tumors
Proceedings Papers

Dynamics of Compound Droplet Passing Through a Conical CTC Microfilter

Pengliang Chang, Mohammad Abul Hashem, Xiaolin Chen, Hua Tan
Proc. ASME. IMECE2019, Volume 7: Fluids Engineering, V007T08A049, November 11–14, 2019
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2019-10519
https://doi.org/10.1115/IMECE2019-10519
View Paper titled, Dynamics of Compound Droplet Passing Through a Conical CTC Microfilter
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Topics: Drops, Dynamics (Mechanics), Pressure
Proceedings Papers

Numerical Study of Joule Heating Effect on Dielectrophoresis-Based Circulating Tumor Cell Separation

Arian Aghilinejad, Mohammad Aghaamoo, Xiaolin Chen
Proc. ASME. IMECE2017, Volume 3: Biomedical and Biotechnology Engineering, V003T04A014, November 3–9, 2017
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2017-70340
https://doi.org/10.1115/IMECE2017-70340
View Paper titled, Numerical Study of Joule Heating Effect on Dielectrophoresis-Based Circulating Tumor Cell Separation
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Topics: Dielectrophoresis, Heating, Joules, Separation (Technology), Tumors, Electric fields, Flow (Dynamics), Computer simulation, Fluids, Temperature
Proceedings Papers

Characterizing the High Reynolds Number Regime for Deterministic Lateral Displacement (DLD) Devices

Brian Dincau, Arian Aghilinejad, Jong-Hoon Kim, Xiaolin Chen
Proc. ASME. IMECE2017, Volume 10: Micro- and Nano-Systems Engineering and Packaging, V010T13A033, November 3–9, 2017
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2017-71892
https://doi.org/10.1115/IMECE2017-71892
View Paper titled, Characterizing the High Reynolds Number Regime for Deterministic Lateral Displacement (DLD) Devices
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Topics: Displacement, Reynolds number, Particulate matter, Columns (Structural), Flow (Dynamics), Separation (Technology), Fluids, Laminar flow, Computer simulation, Computer software
Proceedings Papers

A Numerical Study on Highly Viscous Compound Cancer Cell Microfiltration

Xiaolong Zhang, Xiaolin Chen, Hua Tan
Proc. ASME. IMECE2016, Volume 7: Fluids Engineering, V007T09A052, November 11–17, 2016
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2016-66953
https://doi.org/10.1115/IMECE2016-66953
View Paper titled, A Numerical Study on Highly Viscous Compound Cancer Cell Microfiltration
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Topics: Cancer, Microfiltration, Tumors, Cell membranes, Deformation, Design, Drops, Filters, Filtration, Membranes
Proceedings Papers

The Critical Velocity With Minimum Momentum Change in Pushing a Droplet Through a Constriction Channel

Zhifeng Zhang, Xinpeng Zhao, Jie Xu, Xiaolin Chen
Proc. ASME. IMECE2016, Volume 7: Fluids Engineering, V007T09A055, November 11–17, 2016
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2016-67893
https://doi.org/10.1115/IMECE2016-67893
View Paper titled, The Critical Velocity With Minimum Momentum Change in Pushing a Droplet Through a Constriction Channel
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Topics: Drops, Momentum, Impulse (Physics), Computer simulation, Design, Filters, Microscale devices, Pressure, Surface tension
Proceedings Papers

A Computational Study on Non-Uniform Cross-Sectional Deformability-Based CTC Separation Devices

Mohammad Aghaamoo, Jie Xu, Xiaolin Chen
Proc. ASME. IMECE2015, Volume 3: Biomedical and Biotechnology Engineering, V003T03A034, November 13–19, 2015
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2015-50481
https://doi.org/10.1115/IMECE2015-50481
View Paper titled, A Computational Study on Non-Uniform Cross-Sectional Deformability-Based CTC Separation Devices
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Topics: Separation (Technology), Pressure, Cancer, Blood, Design, Filtration, Tumors, Damage, Diseases, Geometry
Proceedings Papers

Compound Droplet Modelling of Circulating Tumor Cell Microfiltration

Zhifeng Zhang, Jie Xu, Xiaolin Chen
Proc. ASME. IMECE2015, Volume 7B: Fluids Engineering Systems and Technologies, V07BT09A008, November 13–19, 2015
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2015-51957
https://doi.org/10.1115/IMECE2015-51957
View Paper titled, Compound Droplet Modelling of Circulating Tumor Cell Microfiltration
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Topics: Drops, Microfiltration, Modeling, Tumors, Cancer, Pressure, Deformation, Blood, Design, Flow (Dynamics)
Proceedings Papers

Modeling Cell Deformation in CTC Microfluidic Filters

Zhifeng Zhang, Jie Xu, Xiaolin Chen
Proc. ASME. IMECE2014, Volume 3: Biomedical and Biotechnology Engineering, V003T03A034, November 14–20, 2014
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2014-37167
https://doi.org/10.1115/IMECE2014-37167
View Paper titled, Modeling Cell Deformation in CTC Microfluidic Filters
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Topics: Deformation, Filters, Microfluidics, Modeling, Cancer, Design, Cardiovascular system, Fluids, Inspection, Simulation
Proceedings Papers

Predictive Model for the Cell Passing Pressure in Deformation-Based CTC Chips

Zhifeng Zhang, Jie Xu, Xiaolin Chen
Proc. ASME. IMECE2014, Volume 10: Micro- and Nano-Systems Engineering and Packaging, V010T13A043, November 14–20, 2014
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2014-37172
https://doi.org/10.1115/IMECE2014-37172
View Paper titled, Predictive Model for the Cell Passing Pressure in Deformation-Based CTC Chips
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Topics: Deformation, Pressure, Cancer, Surface tension, Blood, Design, Filters, Filtration, Flow (Dynamics), Fluid dynamics
Proceedings Papers

Response Surface Based Optimization of an Electro-Thermal Microactuator for High Track Density Optical Disk Drives

Qikai Xie, Xiaolin Chen
Proc. ASME. IMECE2013, Volume 10: Micro- and Nano-Systems Engineering and Packaging, V010T11A069, November 15–21, 2013
Publisher: American Society of Mechanical Engineers
Paper No: IMECE2013-65375
https://doi.org/10.1115/IMECE2013-65375
View Paper titled, Response Surface Based Optimization of an Electro-Thermal Microactuator for High Track Density Optical Disk Drives
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Topics: Density, Disks, Microactuators, Optimization, Response surface methodology, Design, Mirrors, Displacement, Electronics, Experimental design