The tribological properties of proppant particle sliding on shale rock determine the shale gas production. This work focuses on investigating the impacts of sliding speed on the coefficient of friction (COF) and wear of the silica ball–shale rock contact, which was lubricated by water or different types of polyacrylamide (PAM) aqueous or brine solution. The experimental results show that both boundary and mixed lubrication occur under specific speed and normal load. COF and wear depth of shale rock under water are higher than those under PAM solution due to superior lubrication of PAM. COF of shale rock under PAM brine solution increases and the wear of the rock is more serious, attributed to the corrosion of shale rock and adverse effect on lubrication of PAM by brine.